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Specific Imaging of Bacterial Infection Using 6″-18F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria.
Gowrishankar, Gayatri; Hardy, Jonathan; Wardak, Mirwais; Namavari, Mohammad; Reeves, Robert E; Neofytou, Evgenios; Srinivasan, Ananth; Wu, Joseph C; Contag, Christopher H; Gambhir, Sanjiv Sam.
Afiliación
  • Gowrishankar G; Department of Radiology, Stanford University School of Medicine, Stanford, California.
  • Hardy J; Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
  • Wardak M; Department of Radiology, Stanford University School of Medicine, Stanford, California.
  • Namavari M; Department of Radiology, Stanford University School of Medicine, Stanford, California.
  • Reeves RE; Thermo Fisher Scientific, Hanover Park, Illinois.
  • Neofytou E; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; and.
  • Srinivasan A; Department of Radiology, Stanford University School of Medicine, Stanford, California.
  • Wu JC; Department of Radiology, Stanford University School of Medicine, Stanford, California.
  • Contag CH; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; and.
  • Gambhir SS; Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
J Nucl Med ; 58(10): 1679-1684, 2017 10.
Article en En | MEDLINE | ID: mdl-28490473
6″-18F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like 18F-FDG has been used to image and localize most cancers. However, unlike 18F-FDG, 6″-18F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria. Methods: 6″-18F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice. Results: 6″-18F-fluoromaltotriose was taken up in both gram-positive and gram-negative bacterial strains. 6″-18F-fluoromaltotriose was also able to detect Pseudomonas aeruginosa in a clinically relevant mouse model of wound infection. The utility of 6″-18F-fluoromaltotriose to help monitor antibiotic therapies was also evaluated in rats. Conclusion: 6″-18F-fluoromaltotriose is a promising new tracer that has significant diagnostic utility, with the potential to change the clinical management of patients with infectious diseases of bacterial origin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Polisacáridos / Infecciones Bacterianas / Trisacáridos / Tomografía de Emisión de Positrones Límite: Animals Idioma: En Revista: J Nucl Med Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Polisacáridos / Infecciones Bacterianas / Trisacáridos / Tomografía de Emisión de Positrones Límite: Animals Idioma: En Revista: J Nucl Med Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos