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Development of a rectal sexually transmitted infection (STI) Model in Rhesus macaques using Chlamydia trachomatis serovars E and L2.
Henning, Tara R; Morris, Monica; Ellis, Shanon; Kelley, Kristen; Phillips, Christi; Ritter, Jana; Jones, Tara; Nachamkin, Eli; Chen, Cheng Y; Hong, Jaeyoung; Kang, Joseph; Patton, Dorothy; McNicholl, Janet; Papp, John; Kersh, Ellen N.
Afiliación
  • Henning TR; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Morris M; Total Solutions, Atlanta, GA, USA.
  • Ellis S; Total Solutions, Atlanta, GA, USA.
  • Kelley K; McNeal Professional Services, Atlanta, GA, USA.
  • Phillips C; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Ritter J; Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Jones T; Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Nachamkin E; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Chen CY; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Hong J; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Kang J; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Patton D; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
  • McNicholl J; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Papp J; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Kersh EN; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Med Primatol ; 46(5): 218-227, 2017 10.
Article en En | MEDLINE | ID: mdl-28488731
BACKGROUND: Rectal STI coinfection models enhance the understanding of rectal HIV transmission risk factors. MATERIALS AND METHODS: Rhesus macaques (n=9) were exposed to one of three rectal Chlamydia trachomatis (CT) challenges: C. trachomatis L2 (CT-L2 ); C. trachomatis serovar E (CT-E), followed by CT-L2 ; or CT-E, treatment/clearance, then CT-L2 . Infections were monitored by PCR. Weekly blood and rectal secretion/lavage samples were collected for cytokine analyzes and/or epithelial sloughing, occult, and overt blood determinations. RESULTS: Chlamydial infections were successfully established in each animal, with varying degrees of persistence. Mucosal IL-1beta was upregulated in animals consecutively infected with CT-E then CT-L2 (P=.05). Epithelial sloughing was also significantly increased post-infection in this group (P=.0003). CONCLUSIONS: This study demonstrates successful rectal infection of rhesus macaques with CT-E and CT-L2 and describes measures of assessing rectal inflammation and pathology. Different infection strategies yield varying inflammatory and pathologic outcomes, providing well-described models for future SIV/SHIV susceptibility studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Chlamydia / Enfermedades de Transmisión Sexual / Infecciones por VIH / Chlamydia trachomatis / Modelos Animales de Enfermedad / Macaca mulatta Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Med Primatol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Chlamydia / Enfermedades de Transmisión Sexual / Infecciones por VIH / Chlamydia trachomatis / Modelos Animales de Enfermedad / Macaca mulatta Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Med Primatol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca