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Cold adaptation in pigs depends on UCP3 in beige adipocytes.
Lin, Jun; Cao, Chunwei; Tao, Cong; Ye, Rongcai; Dong, Meng; Zheng, Qiantao; Wang, Chao; Jiang, Xiaoxiao; Qin, Guosong; Yan, Changguo; Li, Kui; Speakman, John R; Wang, Yanfang; Jin, Wanzhu; Zhao, Jianguo.
Afiliación
  • Lin J; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • Cao C; College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
  • Tao C; State Key Laboratory of Stem Cell and Reproductive Biology, Chinese Academy of Sciences, Beijing, China.
  • Ye R; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
  • Dong M; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • Zheng Q; College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
  • Wang C; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • Jiang X; College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
  • Qin G; College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
  • Yan C; State Key Laboratory of Stem Cell and Reproductive Biology, Chinese Academy of Sciences, Beijing, China.
  • Li K; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
  • Speakman JR; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • Wang Y; College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
  • Jin W; State Key Laboratory of Stem Cell and Reproductive Biology, Chinese Academy of Sciences, Beijing, China.
  • Zhao J; Department of Animal Science, Yanbian University, Yanji, China.
J Mol Cell Biol ; 9(5): 364-375, 2017 10 01.
Article en En | MEDLINE | ID: mdl-28486585
Pigs lack functional uncoupling protein 1 (UCP1) making them susceptible to cold. Nevertheless, several pig breeds are known to be cold resistant. The molecular mechanism(s) enabling such adaptation are currently unknown. Here, we show that this resistance is not dependent on shivering, but rather depends on UCP3 and white adipose tissue (WAT) browning. In two cold-resistant breeds (Tibetan and Min), but not a cold-sensitive breed (Bama), WAT browning was induced after cold exposure. Beige adipocytes from Tibetan pigs exhibited greater oxidative capacity than those from Bama pigs. Notably, UCP3 expression was significantly increased only in cold-resistant breeds, and knockdown of UCP3 expression in Tibetan adipocytes phenocopied Bama adipocytes in culture. Moreover, the eight dominant pig breeds found across China can be classified into cold-sensitive and cold-resistant breeds based on the UCP3 cDNA sequence. This study indicates that UCP3 has contributed to the evolution of cold resistance in the pig and overturns the orthodoxy that UCP1 is the only thermogenic uncoupling protein.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adaptación Biológica / Frío / Adipocitos Beige / Proteína Desacopladora 3 Límite: Animals Idioma: En Revista: J Mol Cell Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adaptación Biológica / Frío / Adipocitos Beige / Proteína Desacopladora 3 Límite: Animals Idioma: En Revista: J Mol Cell Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos