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Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values.
Li, Feng-Fei; Liu, Bing-Li; Yan, Reng-Na; Zhu, Hong-Hong; Zhou, Pei-Hua; Li, Hui-Qin; Su, Xiao-Fei; Wu, Jin-Dan; Zhang, Dan-Feng; Ye, Lei; Ma, Jian-Hua.
Afiliación
  • Li FF; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Liu BL; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Yan RN; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Zhu HH; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Zhou PH; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Li HQ; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Su XF; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Wu JD; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Zhang DF; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Ye L; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.
  • Ma JH; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. majianhua196503@126.com.
Sci Rep ; 7(1): 1583, 2017 05 08.
Article en En | MEDLINE | ID: mdl-28484269
To define the features of glycemic variations in drug naïve type 2 diabetic (T2D) patients with different HbA1c values using continuous glucose monitoring (CGM), a total of 195 drug naïve T2D patients were admitted. The subjects were divided into the following groups: lower HbA1c values (≤8%), moderate HbA1c values (>8% and ≤10%), and higher HbA1c values (>10%). The patients underwent oral glucose tolerance tests and were then subjected to 3-day CGM. The primary endpoint was the differences in the 24-hr mean amplitude of glycemic excursions (MAGE) in patients with different HbA1c values. Patients with higher HbA1c values had larger MAGEs than those in the moderate and lower groups (7.44 ± 3.00 vs. 6.30 ± 2.38, P < 0.05, 7.44 ± 3.00 vs. 5.20 ± 2.35, P < 0.01, respectively). The 24-hr mean glucose concentrations increased incrementally in the patients with lower, moderate and higher HbA1c values. Moreover, the patients with higher HbA1c values exhibited higher peak glucose concentrations and prolongation in the time to peak glucose. Patients with higher HbA1c values had larger MAGE compared with those with lower and moderate HbA1c values. Our data indicated patients with higher HbA1c values should receive special therapy aimed at reducing the larger glycemic variations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Hemoglobina Glucada / Diabetes Mellitus Tipo 2 Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Hemoglobina Glucada / Diabetes Mellitus Tipo 2 Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido