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Sex Disparity in Cord Blood FoxP3+ CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero.
Prahl, Mary; Jagannathan, Prasanna; McIntyre, Tara I; Auma, Ann; Wamala, Samuel; Nalubega, Mayimuna; Musinguzi, Kenneth; Naluwu, Kate; Sikyoma, Esther; Budker, Rachel; Odorizzi, Pamela; Kakuru, Abel; Havlir, Diane V; Kamya, Moses R; Dorsey, Grant; Feeney, Margaret E.
Afiliación
  • Prahl M; Departments of Pediatrics and.
  • Jagannathan P; Medicine, University of California-San Francisco.
  • McIntyre TI; Medicine, University of California-San Francisco.
  • Auma A; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Wamala S; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Nalubega M; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Musinguzi K; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Naluwu K; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Sikyoma E; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Budker R; Medicine, University of California-San Francisco.
  • Odorizzi P; Medicine, University of California-San Francisco.
  • Kakuru A; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Havlir DV; Medicine, University of California-San Francisco.
  • Kamya MR; School of Medicine, Makerere University of College of Health Sciences, College of Health Sciences, Kampala, Uganda.
  • Dorsey G; Medicine, University of California-San Francisco.
  • Feeney ME; Departments of Pediatrics and.
Open Forum Infect Dis ; 4(1): ofx022, 2017.
Article en En | MEDLINE | ID: mdl-28480292
Sex differences in the immune response and in infectious disease susceptibility have been well described, although the mechanisms underlying these differences remain incompletely understood. We evaluated the frequency of cord blood CD4 T cell subsets in a highly malaria-exposed birth cohort of mother-infant pairs in Uganda by sex. We found that frequencies of cord blood regulatory T cell ([Treg] CD4+CD25+FoxP3+CD127lo/-) differed by infant sex, with significantly lower frequencies of Tregs in female than in male neonates (P = .006). When stratified by in utero malaria exposure status, this difference was observed in the exposed, but not in the unexposed infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Aspecto: Equity_inequality Idioma: En Revista: Open Forum Infect Dis Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Aspecto: Equity_inequality Idioma: En Revista: Open Forum Infect Dis Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos