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Maternal colonization with Staphylococcus aureus and Group B streptococcus is associated with colonization in newborns.
Roca, A; Bojang, A; Camara, B; Oluwalana, C; Lette, K; West, P; D'Alessandro, U; Bottomley, C.
Afiliación
  • Roca A; Medical Research Council Unit The Gambia, Banjul, Gambia; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: aroca@mrc.gm.
  • Bojang A; Medical Research Council Unit The Gambia, Banjul, Gambia.
  • Camara B; Medical Research Council Unit The Gambia, Banjul, Gambia.
  • Oluwalana C; Medical Research Council Unit The Gambia, Banjul, Gambia.
  • Lette K; Medical Research Council Unit The Gambia, Banjul, Gambia.
  • West P; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
  • D'Alessandro U; Medical Research Council Unit The Gambia, Banjul, Gambia; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Institute of Tropical Medicine, Antwerp, Belgium.
  • Bottomley C; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Clin Microbiol Infect ; 23(12): 974-979, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28478240
OBJECTIVES: Although Staphylococcus aureus and Group B streptococcus (GBS) are major causes of neonatal sepsis in sub-Saharan Africa, it is unclear how these bacteria are transmitted to the neonate. METHODS: In a cohort of 377 Gambian women and their newborns, nasopharyngeal swabs were collected at delivery (day 0), and 3, 6, 14 and 28 days later. Breast milk samples and vaginal swabs were collected from the mother. Staphylococcus aureus and GBS were isolated using conventional microbiological methods. RESULTS: Most women were carriers of S. aureus (264 out of 361 with all samples collected, 73.1%) at some point during follow up and many were carriers of GBS (114 out of 361, 31.6%). Carriage of S. aureus was common in all three maternal sites and GBS was common in the vaginal tract and breast milk. Among newborns, carriage of S. aureus peaked at day 6 (238 out of 377, 63.1%) and GBS at day 3 (39 out of 377, 10.3%). Neonatal carriage of S. aureus at day 6 was associated with maternal carriage in the breast milk adjusted OR 2.54; 95% CI 1.45-4.45, vaginal tract (aOR 2.55; 95% CI 1.32-4.92) and nasopharynx (aOR 2.49; 95% CI 1.56-3.97). Neonatal carriage of GBS at day 6 was associated with maternal carriage in the breast milk (aOR 3.75; 95% CI 1.32-10.65) and vaginal tract (aOR 3.42; 95% CI 1.27-9.22). CONCLUSIONS: Maternal colonization with S. aureus or GBS is a risk factor for bacterial colonization in newborns.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Infecciones Estafilocócicas / Staphylococcus aureus / Infecciones Estreptocócicas / Streptococcus agalactiae / Portador Sano / Transmisión Vertical de Enfermedad Infecciosa Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Infecciones Estafilocócicas / Staphylococcus aureus / Infecciones Estreptocócicas / Streptococcus agalactiae / Portador Sano / Transmisión Vertical de Enfermedad Infecciosa Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido