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DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis.
De Gregoriis, Giuliana; Ramos, Juliene Antonio; Fernandes, Priscila Valverde; Vignal, Giselle Maria; Brianese, Rafael Canfield; Carraro, Dirce Maria; Monteiro, Alvaro N; Struchiner, Claudio José; Suarez-Kurtz, Guilherme; Vianna-Jorge, Rosane; de Carvalho, Marcelo Alex.
Afiliación
  • De Gregoriis G; a Programa de Pesquisa Clínica , Coordenação de Pesquisa, Instituto Nacional de Câncer , Rio de Janeiro , RJ , Brazil.
  • Ramos JA; b Instituto Federal do Rio de Janeiro , Rio de Janeiro , RJ , Brazil.
  • Fernandes PV; c Divisão de Patologia , Instituto Nacional de Câncer , Rio de Janeiro , RJ , Brazil.
  • Vignal GM; c Divisão de Patologia , Instituto Nacional de Câncer , Rio de Janeiro , RJ , Brazil.
  • Brianese RC; d International Research Center, A. C. Camargo Cancer Center , São Paulo , SP , Brazil.
  • Carraro DM; d International Research Center, A. C. Camargo Cancer Center , São Paulo , SP , Brazil.
  • Monteiro AN; e Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute , Tampa , FL , USA.
  • Struchiner CJ; f Programa de Computação Científica, Fundação Oswaldo Cruz , Rio de Janeiro , RJ , Brazil.
  • Suarez-Kurtz G; a Programa de Pesquisa Clínica , Coordenação de Pesquisa, Instituto Nacional de Câncer , Rio de Janeiro , RJ , Brazil.
  • Vianna-Jorge R; a Programa de Pesquisa Clínica , Coordenação de Pesquisa, Instituto Nacional de Câncer , Rio de Janeiro , RJ , Brazil.
  • de Carvalho MA; g Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ , Brazil.
Cancer Biol Ther ; 18(6): 439-449, 2017 06 03.
Article en En | MEDLINE | ID: mdl-28475402
Despite remarkable advances in diagnosis, prognosis and treatment, advanced or recurrent breast tumors have limited therapeutic approaches. Many treatment strategies try to explore the limitations of DNA damage response (DDR) in tumor cells to selectively eliminate them. BRCT (BRCA1 C-terminal) domains are present in a superfamily of proteins involved in cell cycle checkpoints and the DDR. Tandem BRCT domains (tBRCT) represent a distinct class of these domains. We investigated the expression profile of 7 tBRCT genes (BARD1, BRCA1, LIG4, ECT2, MDC1, PAXIP1/PTIP and TP53BP1) in breast cancer specimens and observed a high correlation between PAXIP1 and TP53BP1 gene expression in tumor samples. Tumors with worse prognosis (tumor grade 3 and triple negative) showed reduced expression of tBRCT genes, notably, PAXIP1 and TP53BP1. Survival analyses data indicated that tumor status of both genes may impact prognosis. PAXIP1 and 53BP1 protein levels followed gene expression results, i.e., are intrinsically correlated, and also reduced in more advanced tumors. Evaluation of both genes in triple negative breast tumor samples which were characterized for their BRCA1 status showed that PAXIP1 is overexpressed in BRCA1 mutant tumors. Taken together our findings indicate that PAXIP1 status correlates with breast cancer staging, in a manner similar to what has been characterized for TP53BP1.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Nucleares / Proteínas Portadoras / Biomarcadores de Tumor / Carcinoma Ductal de Mama / Proteína 1 de Unión al Supresor Tumoral P53 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Cancer Biol Ther Asunto de la revista: NEOPLASIAS / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Nucleares / Proteínas Portadoras / Biomarcadores de Tumor / Carcinoma Ductal de Mama / Proteína 1 de Unión al Supresor Tumoral P53 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Cancer Biol Ther Asunto de la revista: NEOPLASIAS / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos