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Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice.
Uraki, Ryuta; Jurado, Kellie Ann; Hwang, Jesse; Szigeti-Buck, Klara; Horvath, Tamas L; Iwasaki, Akiko; Fikrig, Erol.
Afiliación
  • Uraki R; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine.
  • Jurado KA; Department of Immunobiology.
  • Hwang J; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine.
  • Szigeti-Buck K; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
  • Horvath TL; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
  • Iwasaki A; Department of Immunobiology.
  • Fikrig E; Howard Hughes Medical Institute, Chevy Chase, Maryland.
J Infect Dis ; 215(11): 1720-1724, 2017 06 01.
Article en En | MEDLINE | ID: mdl-28472297
Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Enfermedades Virales de Transmisión Sexual / Retardo del Crecimiento Fetal / Virus Zika / Infección por el Virus Zika Límite: Animals / Pregnancy Idioma: En Revista: J Infect Dis Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Enfermedades Virales de Transmisión Sexual / Retardo del Crecimiento Fetal / Virus Zika / Infección por el Virus Zika Límite: Animals / Pregnancy Idioma: En Revista: J Infect Dis Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos