Your browser doesn't support javascript.
loading
Conformational latitude - activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin-1.
Fedorczyk, Bartlomiej; Lipinski, Piotr F J; Tymecka, Dagmara; Puszko, Anna K; Wilenska, Beata; Perret, Gerard Y; Misicka, Aleksandra.
Afiliación
  • Fedorczyk B; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
  • Lipinski PFJ; Department of Neuropeptides, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawinskiego 5, 02-106, Warsaw, Poland.
  • Tymecka D; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
  • Puszko AK; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
  • Wilenska B; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
  • Perret GY; Université Paris 13, Sorbonne Paris Cité, INSERM U1125, 74 rue Marcel Cachin, 93017, Bobigny, France.
  • Misicka A; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
J Pept Sci ; 23(6): 445-454, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28466607
Neuropilin-1 has been found to be overexpressed in several kinds of malignant tumors, and it is postulated that its interaction with the vascular endothelial growth factor 165 leads to progression of tumor vascularization and growth. Several analogues (KxxR) with various conformational latitudes have been synthesized and found as inhibitors of NRP-1. Detailed insight provided by molecular dynamics simulation allowed forming a clear relationship between flexibility of xx part of the molecule and its inhibitory activity.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Neuropilina-1 / Factor A de Crecimiento Endotelial Vascular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Pept Sci Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Neuropilina-1 / Factor A de Crecimiento Endotelial Vascular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Pept Sci Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido