Developmental activities of the complement pathway in migrating neurons.
Nat Commun
; 8: 15096, 2017 05 02.
Article
en En
| MEDLINE
| ID: mdl-28462915
In recent years the notion that malfunctioning of the immune system may result in developmental brain diseases has emerged. However, the role of immune molecules in the developing brain has not been well explored. The complement pathway converges to cleave C3. Here we show that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown mice. Molecular mimics of C3 cleavage products rescue the migration defects that have been seen following knockdown of C3 or Masp2. Pharmacological activation of the downstream receptors rescue Masp2 and C3 knockdown as well as C3 knockout. Therefore, we propose that the complement pathway is functionally important in migrating neurons of the developing cortex.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complemento C3
/
Regulación del Desarrollo de la Expresión Génica
/
Lectina de Unión a Manosa de la Vía del Complemento
/
Serina Proteasas Asociadas a la Proteína de Unión a la Manosa
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Israel
Pais de publicación:
Reino Unido