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Transmission fitness of drug-resistant HIV revealed in a surveillance system transmission network.
Wertheim, Joel O; Oster, Alexandra M; Johnson, Jeffrey A; Switzer, William M; Saduvala, Neeraja; Hernandez, Angela L; Hall, H Irene; Heneine, Walid.
Afiliación
  • Wertheim JO; Department of Medicine, University of California, San Diego, CA, 92093, USA.
  • Oster AM; ICF International, Atlanta, GA, 30329, USA.
  • Johnson JA; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
  • Switzer WM; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
  • Saduvala N; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
  • Hernandez AL; ICF International, Atlanta, GA, 30329, USA.
  • Hall HI; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
  • Heneine W; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
Virus Evol ; 3(1): vex008, 2017 Jan.
Article en En | MEDLINE | ID: mdl-28458918
Test-and-treat programs are central to the global control of HIV, but transmitted drug resistance threatens the effectiveness of these programs. HIV mutations conferring resistance to antiretroviral drugs reduce replicative fitness in vitro, but their effect on propagation in vivo is less understood. Here, we estimate transmission fitness of these mutations in antiretroviral-naïve populations in the U.S. National HIV Surveillance System by comparing their frequency of clustering in a genetic transmission network relative with wild-type viruses. The large dataset (66,221 persons), comprising 30,196 antiretroviral-naïve persons, permitted the evaluation of sixty-nine resistance mutations. Decreased transmission fitness was demonstrated for twenty-three mutations, including M184V. In contrast, many high prevalence mutations (e.g. K103N, Y181C, and L90M) had transmission fitness that was indistinguishable from or exceeded wild-type fitness, permitting the establishment of large, self-sustaining drug resistance reservoirs. We highlight implications of these findings on strategies to preserve global treatment effectiveness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies / Screening_studies Idioma: En Revista: Virus Evol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies / Screening_studies Idioma: En Revista: Virus Evol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido