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In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases.
Oshima, Go; Guo, Nining; He, Chunbai; Stack, Melinda E; Poon, Christopher; Uppal, Abhineet; Wightman, Sean C; Parekh, Akash; Skowron, Kinga B; Posner, Mitchell C; Lin, Wenbin; Khodarev, Nikolai N; Weichselbaum, Ralph R.
Afiliación
  • Oshima G; Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
  • Guo N; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
  • He C; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
  • Stack ME; Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
  • Poon C; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
  • Uppal A; Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
  • Wightman SC; Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
  • Parekh A; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA.
  • Skowron KB; Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
  • Posner MC; Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
  • Lin W; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA. Electronic address: wenbinlin@uchicago.edu.
  • Khodarev NN; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA; Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address: n-khodarev@uchicago.edu.
  • Weichselbaum RR; Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA; Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address: rrw@radonc.uchicago.edu.
Mol Ther ; 25(7): 1588-1595, 2017 07 05.
Article en En | MEDLINE | ID: mdl-28457664
Multiple therapeutic agents are typically used in concert to effectively control metastatic tumors. Recently, we described microRNAs that are associated with the oligometastatic state, in which a limited number of metastatic tumors progress to more favorable outcomes. Here, we report the effective delivery of an oligometastatic microRNA (miR-655-3p) to colorectal liver metastases using nanoscale coordination polymers (NCPs). The NCPs demonstrated a targeted and prolonged distribution of microRNAs to metastatic liver tumors. Tumor-targeted microRNA miR-655-3p suppressed tumor growth when co-delivered with oxaliplatin, suggesting additive or synergistic interactions between microRNAs and platinum drugs. This is the first known example of systemically administered nanoparticles delivering an oligometastatic microRNA to advanced metastatic liver tumors and demonstrating tumor-suppressive effects. Our results suggest a potential therapeutic strategy for metastatic liver disease by the co-delivery of microRNAs and conventional cytotoxic agents using tumor-specific NCPs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Neoplasias Colorrectales / Regulación Neoplásica de la Expresión Génica / MicroARNs / Nanoestructuras / Neoplasias Hepáticas / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Neoplasias Colorrectales / Regulación Neoplásica de la Expresión Génica / MicroARNs / Nanoestructuras / Neoplasias Hepáticas / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos