Your browser doesn't support javascript.
loading
Safety of BTZ retreatment for patients with low-grade peripheral neuropathy during the initial treatment.
Vidisheva, Aleksandra P; Wang, James; Spektor, Tanya M; Bitran, Jacob D; Lutzky, Jose; Tabbara, Imad A; Ye, Joseph Z; Ailawadhi, Sikander; Stampleman, Laura V; Steis, Ronald G; Moezi, Mehdi M; Swift, Regina A; Maluso, Tina M; Udd, Kyle A; Eshaghian, Shahrooz; Nassir, Youram; Berenson, James R.
Afiliación
  • Vidisheva AP; Oncotherapeutics, West Hollywood, CA, USA.
  • Wang J; James R. Berenson, MD, Inc., West Hollywood, CA, USA.
  • Spektor TM; Institute for Myeloma and Bone Cancer Research, 9201 W. Sunset Blvd., Suite 300, West Hollywood, CA, 90069, USA.
  • Bitran JD; Oncotherapeutics, West Hollywood, CA, USA.
  • Lutzky J; Oncology Specialist Research Institute, Park Ridge, IL, USA.
  • Tabbara IA; Mount Sinai Medical Center, Miami Beach, FL, USA.
  • Ye JZ; George Washington University, Washington, DC, USA.
  • Ailawadhi S; Vista Oncology, Olympia, WA, USA.
  • Stampleman LV; University of Southern California, Los Angeles, CA, USA.
  • Steis RG; Pacific Cancer Care, Monterey, CA, USA.
  • Moezi MM; Atlanta Cancer Care, Atlanta, GA, USA.
  • Swift RA; Cancer Specialists of North Florida, Jacksonville, FL, USA.
  • Maluso TM; James R. Berenson, MD, Inc., West Hollywood, CA, USA.
  • Udd KA; James R. Berenson, MD, Inc., West Hollywood, CA, USA.
  • Eshaghian S; James R. Berenson, MD, Inc., West Hollywood, CA, USA.
  • Nassir Y; James R. Berenson, MD, Inc., West Hollywood, CA, USA.
  • Berenson JR; James R. Berenson, MD, Inc., West Hollywood, CA, USA.
Support Care Cancer ; 25(10): 3217-3224, 2017 10.
Article en En | MEDLINE | ID: mdl-28455546
OBJECTIVE: Neuropathy is an important complication that may limit treatment options for patients with multiple myeloma. Previous studies have focused on treatment efficacy and have shown that retreatment with bortezomib (BTZ) is an effective treatment option. The goal of this study was to focus on the clinical manifestations of peripheral neuropathy (PN) and to retrospectively compare the incidence and severity of PN between the initial BTZ regimen and upon retreatment. Furthermore, this study evaluated how certain factors affect BIPN, which will help determine what conditions should be considered prior to retreatment. METHODS: Charts were reviewed from 93 patients who were retreated with a BTZ-containing regimen after previously being treated with this drug. RESULTS: Among the patients who developed PN, most patients in the study had low-grade neuropathy during the initial BTZ treatment (n = 52, 68%). The results showed no evidence of cumulative toxicity, and there was no significant difference in the incidence and severity of PN upon retreatment. Factors such as the presence of baseline PN, number of prior treatments, dose of BTZ, and comorbidities did not increase the severity of PN upon retreatment. The lapse of time between the two regimens also did not affect the severity of PN. CONCLUSION: The results suggest that retreatment with BTZ may be a feasible option, without additional risks of PN, for MM patients even with peripheral neuropathy during their initial treatment with this drug.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Periférico / Bortezomib / Mieloma Múltiple / Antineoplásicos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Periférico / Bortezomib / Mieloma Múltiple / Antineoplásicos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania