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Evaluation of Adenovirus-36 (Ad-36) antibody seropositivity and adipokine levels in obese children.
Kocazeybek, Bekir; Dinc, Harika Oyku; Ergin, Sevgi; Saribas, Suat; Ozcabi, Bahar Taskin; Cizmecigil, Utku; Altan, Eda; Atalik, Kevser; Yüksel, Pelin; Taner, Zeynep; Karakullukcu, Asiye; Sirekbasan, Serhat; Turan, Nuri; Cagatay, Penbe; Imamova, Nergiz; Evliyaoglu, Olcay; Yilmaz, Huseyin.
Afiliación
  • Kocazeybek B; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey. Electronic address: bzeybek@istanbul.edu.tr.
  • Dinc HO; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Ergin S; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Saribas S; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Ozcabi BT; Istanbul University, Cerrahpasa Medical Faculty, Department of Child Health and Diseases, Istanbul, Turkey.
  • Cizmecigil U; Istanbul University, Veterinary Faculty, Department of Virology, Avcilar, Istanbul, Turkey.
  • Altan E; Istanbul University, Veterinary Faculty, Department of Virology, Avcilar, Istanbul, Turkey.
  • Atalik K; Istanbul University, Istanbul Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Yüksel P; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Taner Z; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Karakullukcu A; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Sirekbasan S; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Turan N; Istanbul University, Veterinary Faculty, Department of Virology, Avcilar, Istanbul, Turkey.
  • Cagatay P; Istanbul University, Cerrahpasa Medical Faculty, Vocational School of Health Services, Istanbul, Turkey.
  • Imamova N; Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Microbiology, Istanbul, Turkey.
  • Evliyaoglu O; Istanbul University, Cerrahpasa Medical Faculty, Department of Child Health and Diseases, Istanbul, Turkey.
  • Yilmaz H; Istanbul University, Veterinary Faculty, Department of Virology, Avcilar, Istanbul, Turkey.
Microb Pathog ; 108: 27-31, 2017 Jul.
Article en En | MEDLINE | ID: mdl-28455139
Adenovirus 36 (Ad-36) has recently been suggested as a possible contributor to the current obesity epidemic. The aim of this study was to investigate the prevalence of Ad-36 antibodies in obese children, as well as investigate the role of serum leptin and lipid levels in Ad-36-obesity. Seventy-one obese children and 62 non-obese children were included as the patient group (PG), including the healthy control group (HCG), respectively. Simultaneously, Ad-36 antibodies and adipokine levels were assessed with serum neutralization assays (SNA) and ELISA. Ad-36 antibody was detected in 9 patients (12.7%) and 1 patient (1.6%) in both the PG and HCG, respectively, while a significant difference was detected between groups (p < 0.05). Although serum LDL, total cholesterol, triglycerides and leptin levels were detected significantly higher, adiponectin level was detected paradoxically lower in the PG. However, a significant difference was not detected for lipids and leptin levels; adiponectin levels were found to be significantly lower in Ad-36 antibody-positive PG (p < 0.05). In conclusion, we suggest there is an association between Ad-36 and obesity in children, including IL-6 levels increasing in obese children with Ad-36 seropositivity. Conversely, adiponectin levels in obese children with Ad-36 seropositivity were higher. As such, there is a need for studies to understand the mechanisms underlying this observation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenovirus Humanos / Adipoquinas / Anticuerpos Antivirales / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenovirus Humanos / Adipoquinas / Anticuerpos Antivirales / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido