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Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis.
Eriksson, Joel; Haring, Robin; Grarup, Niels; Vandenput, Liesbeth; Wallaschofski, Henri; Lorentzen, Erik; Hansen, Torben; Mellström, Dan; Pedersen, Oluf; Nauck, Matthias; Lorentzon, Mattias; Nystrup Husemoen, Lise Lotte; Völzke, Henry; Karlsson, Magnus; Baumeister, Sebastian E; Linneberg, Allan; Ohlsson, Claes.
Afiliación
  • Eriksson J; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Haring R; University Medicine Greifswald, Institute of Clinical Chemistry and Laboratory Medicine, Greifswald, Germany.
  • Grarup N; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
  • Vandenput L; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Wallaschofski H; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Lorentzen E; University Medicine Greifswald, Institute of Clinical Chemistry and Laboratory Medicine, Greifswald, Germany.
  • Hansen T; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Mellström D; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Pedersen O; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Nauck M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lorentzon M; University Medicine Greifswald, Institute of Clinical Chemistry and Laboratory Medicine, Greifswald, Germany.
  • Nystrup Husemoen LL; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Völzke H; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Karlsson M; Research Centre for Prevention and Health, the Capital Region, Copenhagen, Denmark.
  • Baumeister SE; University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany.
  • Linneberg A; Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics and Clinical Sciences, Lund University, Skåne University Hospital (SUS), Malmö, Sweden.
  • Ohlsson C; University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany.
PLoS One ; 12(4): e0176277, 2017.
Article en En | MEDLINE | ID: mdl-28448539
CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. DESIGN: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. SETTING: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden). PARTICIPANTS: 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs. MAIN OUTCOME MEASURES: BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site. RESULTS: 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349). CONCLUSIONS: Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Análisis de la Aleatorización Mendeliana / Obesidad Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Aged / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Análisis de la Aleatorización Mendeliana / Obesidad Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Aged / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos