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Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis.
Heath, Paul T; Culley, Fiona J; Jones, Christine E; Kampmann, Beate; Le Doare, Kirsty; Nunes, Marta C; Sadarangani, Manish; Chaudhry, Zain; Baker, Carol J; Openshaw, Peter J M.
Afiliación
  • Heath PT; Vaccine Institute, Institute for Infection and Immunity, St George's, University of London and St George's University Hospitals NHS Foundation Trust, London, UK. Electronic address: pheath@sgul.ac.uk.
  • Culley FJ; Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
  • Jones CE; Faculty of Medicine and Institute for Life Sciences, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Kampmann B; Centre for International Child Health, Department of Paediatrics, Imperial College London, London, UK; Medical Research Council Unit, Serrekunda, The Gambia.
  • Le Doare K; Vaccine Institute, Institute for Infection and Immunity, St George's, University of London and St George's University Hospitals NHS Foundation Trust, London, UK; Centre for International Child Health, Department of Paediatrics, Imperial College London, London, UK.
  • Nunes MC; Department of Science and Technology and National Research Foundation, Vaccine Preventable Diseases and Medical Research Council, University of the Witwatersrand, Faculty of Health Science, Johannesburg, South Africa; Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand
  • Sadarangani M; Department of Paediatrics, University of Oxford, Oxford, UK; Vaccine Evaluation Centre, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
  • Chaudhry Z; Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
  • Baker CJ; Department of Pediatrics, Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
  • Openshaw PJM; Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
Lancet Infect Dis ; 17(7): e223-e234, 2017 07.
Article en En | MEDLINE | ID: mdl-28433702
Group B streptococcus and respiratory syncytial virus are leading causes of infant morbidity and mortality worldwide. No licensed vaccines are available for either disease, but vaccines for both are under development. Severe respiratory syncytial virus disease can be prevented by passively administered antibody. The presence of maternal IgG antibody specific to respiratory syncytial virus is associated with reduced prevalence and severity of respiratory syncytial virus disease in the first few weeks of life, whereas maternal serotype-specific anticapsular antibody is associated with protection against both early-onset and late-onset group B streptococcus disease. Therefore, vaccination in pregnancy might protect infants against both diseases. This report describes what is known about immune protection against group B streptococcus and respiratory syncytial virus, identifies knowledge gaps regarding the immunobiology of both diseases, and aims to prioritise research directions in maternal immunisation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Inmunización / Infecciones por Virus Sincitial Respiratorio / Vacunas Estreptocócicas / Vacunas contra Virus Sincitial Respiratorio / Inmunidad Materno-Adquirida Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Infant / Pregnancy Idioma: En Revista: Lancet Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Inmunización / Infecciones por Virus Sincitial Respiratorio / Vacunas Estreptocócicas / Vacunas contra Virus Sincitial Respiratorio / Inmunidad Materno-Adquirida Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Infant / Pregnancy Idioma: En Revista: Lancet Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos