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Relationship Between Urinary Nitrate Excretion and Blood Pressure in the InChianti Cohort.
Smallwood, Miranda J; Ble, Alessandro; Melzer, David; Winyard, Paul G; Benjamin, Nigel; Shore, Angela C; Gilchrist, Mark.
Afiliación
  • Smallwood MJ; NIHR Clinical Research Facility, University of Exeter Medical School, Exeter, Devon, UK.
  • Ble A; NIHR Clinical Research Facility, University of Exeter Medical School, Exeter, Devon, UK.
  • Melzer D; NIHR Clinical Research Facility, University of Exeter Medical School, Exeter, Devon, UK.
  • Winyard PG; NIHR Clinical Research Facility, University of Exeter Medical School, Exeter, Devon, UK.
  • Benjamin N; NIHR Clinical Research Facility, University of Exeter Medical School, Exeter, Devon, UK.
  • Shore AC; NIHR Clinical Research Facility, University of Exeter Medical School, Exeter, Devon, UK.
  • Gilchrist M; NIHR Clinical Research Facility, University of Exeter Medical School, Exeter, Devon, UK.
Am J Hypertens ; 30(7): 707-712, 2017 Jul 01.
Article en En | MEDLINE | ID: mdl-28430835
BACKGROUND: Inorganic nitrate from the oxidation of endogenously synthesized nitric oxide (NO) or consumed in the diet can be reduced to NO via a complex enterosalivary circulation pathway. The relationship between total nitrate exposure by measured urinary nitrate excretion and blood pressure in a large population sample has not been assessed previously. METHODS: For this cross-sectional study, 24-hour urinary nitrate excretion was measured by spectrophotometry in the 919 participants from the InChianti cohort at baseline and blood pressure measured with a mercury sphygmomanometer. RESULTS: After adjusting for age and sex only, diastolic blood pressure was 1.9 mm Hg lower in subjects with ≥2 mmol urinary nitrate excretion compared with those excreting <1 mmol nitrate in 24 hours: systolic blood pressure was 3.4 mm Hg (95% confidence interval (CI): -3.5 to -0.4) lower in subjects for the same comparison. Effect sizes in fully adjusted models (for age, sex, potassium intake, use of antihypertensive medications, diabetes, HS-CRP, or current smoking status) were marginally larger: systolic blood pressure in the ≥2 mmol urinary nitrate excretion group was 3.9 (CI: -7.1 to -0.7) mm Hg lower than in the comparison <1 mmol excretion group. CONCLUSIONS: Modest differences in total nitrate exposure are associated with lower blood pressure. These differences are at least equivalent to those seen from substantial (100 mmol) reductions in sodium intake.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertensión / Nitratos Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Am J Hypertens Asunto de la revista: ANGIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertensión / Nitratos Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Am J Hypertens Asunto de la revista: ANGIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos