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Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension.
Jenner, Raimundo; Fatureto-Borges, Fernanda; Costa-Hong, Valéria; Lopes, Heno F; Teixeira, Sandra H; Marum, Elias; Giorgi, Dante A M; Consolim-Colombo, Fernanda M; Bortolotto, Luiz A; Lorenzi-Filho, Geraldo; Krieger, Eduardo M; Drager, Luciano F.
Afiliación
  • Jenner R; Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Fatureto-Borges F; Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Costa-Hong V; Universidade UNINOVE, São Paulo, Brazil.
  • Lopes HF; Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Teixeira SH; Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Marum E; Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Giorgi DAM; Universidade UNINOVE, São Paulo, Brazil.
  • Consolim-Colombo FM; Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Bortolotto LA; Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Lorenzi-Filho G; Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Krieger EM; Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Drager LF; Universidade UNINOVE, São Paulo, Brazil.
J Clin Hypertens (Greenwich) ; 19(9): 910-918, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28429850
Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1±2.2 vs 12.7±2.4 m/s, P=.04; women: 11.8±2.4 vs 13.2±2.2 m/s, P=.03). The proportion of diastolic dysfunction was significant in men and women with OSA. Compared with non-OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (ß=1.050; P=.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08-8.55; P=.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Enfermedades Cardiovasculares / Apnea Obstructiva del Sueño / Rigidez Vascular / Hipertensión Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Enfermedades Cardiovasculares / Apnea Obstructiva del Sueño / Rigidez Vascular / Hipertensión Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos