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Effect of alpha-lipoic acid on endometrial implants in an experimental rat model.
Pinar, Neslihan; Soylu Karapinar, Oya; Özcan, Oguzhan; Özgür, Tümay; Bayraktar, Suphi.
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  • Pinar N; Department of Medical Pharmacology, School of Medicine, Mustafa Kemal University, Hatay, Turkey, 31100.
  • Soylu Karapinar O; Department of Obstetrics and Gynaecology, School of Medicine, Mustafa Kemal University, Hatay, Turkey, 31100.
  • Özcan O; Department of Biochemistry, School of Medicine, Mustafa Kemal University, Hatay, Turkey, 31100.
  • Özgür T; Department of Pathology, School of Medicine, Mustafa Kemal University, Hatay, Turkey, 31100.
  • Bayraktar S; Department of Medical Microbiology, School of Medicine, Cukurova University, Adana, Turkey, 01330.
Fundam Clin Pharmacol ; 31(5): 506-512, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28429826
To investigate the antioxidant and anti-inflammatory effects of alpha-lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre- and post-treatment. Tumor necrosis factor alpha (TNF-α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF-α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha-lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti-inflammatory effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Tióctico / Modelos Animales de Enfermedad / Endometriosis / Endometrio / Autoinjertos / Antioxidantes Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Fundam Clin Pharmacol Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Tióctico / Modelos Animales de Enfermedad / Endometriosis / Endometrio / Autoinjertos / Antioxidantes Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Fundam Clin Pharmacol Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido