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Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes.
Possin, Katherine L; Kim, Hosung; Geschwind, Michael D; Moskowitz, Tacie; Johnson, Erica T; Sha, Sharon J; Apple, Alexandra; Xu, Duan; Miller, Bruce L; Finkbeiner, Steven; Hess, Christopher P; Kramer, Joel H.
Afiliación
  • Possin KL; Department of Neurology, University of California, San Francisco, San Francisco, California, USA; Hellman Family Foundation Alzheimer's Disease Research Program, San Francisco, California, USA. Electronic address: Katherine.Possin@ucsf.edu.
  • Kim H; Department of Radiology, University of California, San Francisco, USA.
  • Geschwind MD; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Moskowitz T; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Johnson ET; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Sha SJ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Apple A; Department of Radiology, University of California, San Francisco, USA.
  • Xu D; Department of Radiology, University of California, San Francisco, USA.
  • Miller BL; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Finkbeiner S; Hellman Family Foundation Alzheimer's Disease Research Program, San Francisco, California, USA; Gladstone Institute of Neurological Disease, San Francisco, CA, USA; Departments of Neurology and Physiology, University of California, San Francisco, CA, USA; Keck Program in Brain Cell Engineering, Glad
  • Hess CP; Department of Neurology, University of California, San Francisco, San Francisco, California, USA; Department of Radiology, University of California, San Francisco, USA.
  • Kramer JH; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Neuropsychologia ; 101: 57-64, 2017 Jul 01.
Article en En | MEDLINE | ID: mdl-28427989
Our brains represent spatial information in egocentric (self-based) or allocentric (landmark-based) coordinates. Rodent studies have demonstrated a critical role for the caudate in egocentric navigation and the hippocampus in allocentric navigation. We administered tests of egocentric and allocentric working memory to individuals with premotor Huntington's disease (pmHD), which is associated with early caudate nucleus atrophy, and controls. Each test had 80 trials during which subjects were asked to remember 2 locations over 1-sec delays. The only difference between these otherwise identical tests was that locations could only be coded in self-based or landmark-based coordinates. We applied a multiatlas-based segmentation algorithm and computed point-wise Jacobian determinants to measure regional variations in caudate and hippocampal volumes from 3T MRI. As predicted, the pmHD patients were significantly more impaired on egocentric working memory. Only egocentric accuracy correlated with caudate volumes, specifically the dorsolateral caudate head, right more than left, a region that receives dense efferents from dorsolateral prefrontal cortex. In contrast, only allocentric accuracy correlated with hippocampal volumes, specifically intermediate and posterior regions that connect strongly with parahippocampal and posterior parietal cortices. These results indicate that the distinction between egocentric and allocentric navigation applies to working memory. The dorsolateral caudate is important for egocentric working memory, which can explain the disproportionate impairment in pmHD. Allocentric working memory, in contrast, relies on the hippocampus and is relatively spared in pmHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoimagen / Percepción Social / Núcleo Caudado / Enfermedad de Huntington / Hipocampo / Memoria a Corto Plazo Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuropsychologia Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoimagen / Percepción Social / Núcleo Caudado / Enfermedad de Huntington / Hipocampo / Memoria a Corto Plazo Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuropsychologia Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido