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Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
Zhang, Haoyang; Wu, Wenkui; Feng, Chao; Liu, Zhaogang; Bai, Enhe; Wang, Xueyuan; Lei, Meng; Cheng, Hao; Feng, Huayun; Shi, Jingmiao; Wang, Jia; Zhang, Zhao; Jin, Tao; Chen, Shanshan; Hu, Shihe; Zhu, Yongqiang.
Afiliación
  • Zhang H; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
  • Wu W; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
  • Feng C; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China.
  • Liu Z; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China.
  • Bai E; College of Science, Nanjing Forestry University, No. 159 Longpan Road, Nanjing 210037, PR China.
  • Wang X; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
  • Lei M; College of Science, Nanjing Forestry University, No. 159 Longpan Road, Nanjing 210037, PR China.
  • Cheng H; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China.
  • Feng H; College of Science, Nanjing Forestry University, No. 159 Longpan Road, Nanjing 210037, PR China.
  • Shi J; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China.
  • Wang J; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China.
  • Zhang Z; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
  • Jin T; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China.
  • Chen S; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China.
  • Hu S; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China. Electronic address: hsh.2@163.com.
  • Zhu Y; College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210046, PR China. Electronic address: zhyqscu@hotmail.com.
Eur J Med Chem ; 135: 12-23, 2017 Jul 28.
Article en En | MEDLINE | ID: mdl-28426996
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Receptores ErbB Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Receptores ErbB Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article Pais de publicación: Francia