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Global Fecal and Plasma Metabolic Dynamics Related to Helicobacter pylori Eradication.
Yap, Theresa Wan-Chen; Leow, Alex Hwong-Ruey; Azmi, Ahmad Najib; Callahan, Damien L; Perez-Perez, Guillermo I; Loke, Mun-Fai; Goh, Khean-Lee; Vadivelu, Jamuna.
Afiliación
  • Yap TW; Department of Medical Microbiology, Faculty of Medicine, University of MalayaKuala Lumpur, Malaysia.
  • Leow AH; Department of Medicine, Faculty of Medicine, University of MalayaKuala Lumpur, Malaysia.
  • Azmi AN; Department of Medicine, Faculty of Medicine, University of MalayaKuala Lumpur, Malaysia.
  • Callahan DL; Faculty of Medicine and Health Sciences, Universiti Sains Islam MalaysiaKuala Lumpur, Malaysia.
  • Perez-Perez GI; Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin UniversityGeelong, VIC, Australia.
  • Loke MF; Department of Medicine, New York University School of MedicineNew York, NY, USA.
  • Goh KL; Department of Microbiology, New York University School of MedicineNew York, NY, USA.
  • Vadivelu J; Department of Medical Microbiology, Faculty of Medicine, University of MalayaKuala Lumpur, Malaysia.
Front Microbiol ; 8: 536, 2017.
Article en En | MEDLINE | ID: mdl-28424674
Background:Helicobacter pylori colonizes the gastric mucosa of more than half of the world's population. There is increasing evidence H. pylori protects against the development of obesity and childhood asthma/allergies in which the development of these diseases coincide with transient dysbiosis. However, the mechanism underlying the association of H. pylori eradication with human metabolic and immunological disorders is not well-established. In this study, we aimed to investigate the local and systemic effects of H. pylori eradication through untargeted fecal lipidomics and plasma metabolomics approaches by liquid chromatography mass spectrometry (LC-MS). Results: Our study revealed that eradication of H. pylori eradication (i.e., loss of H. pylori and/or H. pylori eradication therapy) changed many global metabolite/lipid features, with the majority being down-regulated. Our findings primarily show that H. pylori eradication affects the host energy and lipid metabolism which may eventually lead to the development of metabolic disorders. Conclusion: These predictive metabolic signatures of metabolic and immunological disorders following H. pylori eradication can provide insights into dynamic local and systemic metabolism related to H. pylori eradication in modulating human health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Microbiol Año: 2017 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Microbiol Año: 2017 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Suiza