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A(H1N1)pdm09 influenza infection: vaccine inefficiency.
Friedman, Nehemya; Drori, Yaron; Pando, Rakefet; Glatman-Freedman, Aharona; Sefty, Hanna; Bassal, Ravit; Stein, Yaniv; Shohat, Tamy; Mendelson, Ella; Hindiyeh, Musa; Mandelboim, Michal.
Afiliación
  • Friedman N; Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat-Gan, Israel.
  • Drori Y; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Pando R; Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat-Gan, Israel.
  • Glatman-Freedman A; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Sefty H; The Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Israel.
  • Bassal R; The Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Israel.
  • Stein Y; Departments of Pediatrics and Family and Community Medicine, Valhalla, New York, USA.
  • Shohat T; The Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Israel.
  • Mendelson E; The Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Israel.
  • Hindiyeh M; The Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Israel.
  • Mandelboim M; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Oncotarget ; 8(20): 32856-32863, 2017 May 16.
Article en En | MEDLINE | ID: mdl-28415629
The last influenza pandemic, caused by the swine A(H1N1)pdm09 influenza virus, began in North America at 2009. Since then, the World Health Organization (WHO) recommended integration of the swine-based virus A/California/07/2009 strain in yearly vaccinations. Yet, infections with A(H1N1)pdm09 have continued in subsequent years. The reasons for this are currently unknown. During the 2015-2016 influenza season, we noted an increased prevalence of A(H1N1)pdm09 influenza virus infection in Israel. Our phylogenetic analysis indicated that the circulating A(H1N1)pdm09 strains belonged to 6B.1 and 6B.2 clades and differed from the vaccinating strain, with approximately 18 amino acid differences found between the circulating strains and the immunizing A/California/07/2009 strain. Hemmaglutination inhibition (HI) assays demonstrated higher antibodies titer against the A/California/07/2009 vaccinating strain as compared to the circulating Israeli strains. We thus suggest that the current vaccination was not sufficiently effective and propose inclusion of the current circulating A(H1N1)pdm09 influenza viruses in the annual vaccine composition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos