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Supramolecular Photoactivatable Anticancer Hydrogels.
Venkatesh, V; Mishra, Narendra Kumar; Romero-Canelón, Isolda; Vernooij, Robbin R; Shi, Huayun; Coverdale, James P C; Habtemariam, Abraha; Verma, Sandeep; Sadler, Peter J.
Afiliación
  • Venkatesh V; Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
  • Mishra NK; Department of Chemistry and Center for Nanoscience and Soft Nanotechnology, Indian Institute of Technology Kanpur , Kanpur 208016, Uttar Pradesh, India.
  • Romero-Canelón I; Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
  • Vernooij RR; Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
  • Shi H; Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
  • Coverdale JPC; Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
  • Habtemariam A; Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
  • Verma S; Department of Chemistry and Center for Nanoscience and Soft Nanotechnology, Indian Institute of Technology Kanpur , Kanpur 208016, Uttar Pradesh, India.
  • Sadler PJ; Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
J Am Chem Soc ; 139(16): 5656-5659, 2017 04 26.
Article en En | MEDLINE | ID: mdl-28414222
A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K+ borate hydrogels by using borate ester linkages (Pt-G4K+B hydrogel). These were characterized by 11B NMR, attenuated total reflection Fourier transform infrared spectroscopy, circular dichroism, scanning electron microscopy and transmission electron microscopy. Microscopy investigations revealed the transformation of an extended fiber assembly into discrete flakes after incorporation of Pt-DA. Pt-DA showed photocytotoxicity against cisplatin-resistant A2780Cis human ovarian cancer cells (IC50 74 µM, blue light) with a photocytotoxic index <2, whereas Pt-G4K+B hydrogels exhibited more potent photocytotoxicity (IC50 3 µM, blue light) with a photocytotoxic index >5. Most notably, Pt-DA and Pt-G4K+B hydrogels show selective phototoxicity for cancer cells versus normal fibroblast cells (MRC5).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Boratos / Cisplatino / Hidrogeles / Antineoplásicos Límite: Humans Idioma: En Revista: J Am Chem Soc Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Boratos / Cisplatino / Hidrogeles / Antineoplásicos Límite: Humans Idioma: En Revista: J Am Chem Soc Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos