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Characterization of human induced pluripotent stem cell (iPSC) line from a 72year old male patient with later onset Alzheimer's disease.
Zhang, Shaokun; Lv, Zhenshan; Zhang, Songyuan; Liu, Lidi; Li, Qiao; Gong, Weiquan; Sha, Hui; Wu, Hong.
Afiliación
  • Zhang S; Department of Spine Surgery, The 1st Hospital of Jilin University, Changchun 130021, China.
  • Lv Z; Department of Spine Surgery, The 1st Hospital of Jilin University, Changchun 130021, China.
  • Zhang S; Department of Spine Surgery, The 1st Hospital of Jilin University, Changchun 130021, China.
  • Liu L; Department of Spine Surgery, The 1st Hospital of Jilin University, Changchun 130021, China.
  • Li Q; Department of Spine Surgery, The 1st Hospital of Jilin University, Changchun 130021, China.
  • Gong W; Department of Spine Surgery, The 1st Hospital of Jilin University, Changchun 130021, China.
  • Sha H; Department of Spine Surgery, The 1st Hospital of Jilin University, Changchun 130021, China.
  • Wu H; Department of Ophthalmology, The 2nd Hospital of Jilin University, Changchun 130041, China.
Stem Cell Res ; 19: 34-36, 2017 03.
Article en En | MEDLINE | ID: mdl-28413002
Peripheral blood was collected from a clinically diagnosed 72-year old male patient with later onset Alzheimer's disease. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pluripotency markers, and the iPSC line was able to differentiate into the 3 germ layers in vivo. The iPSC line also showed normal karyotype. This in vitro cellular model will be useful for studying the pathological mechanism of Alzheimer's disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Pluripotentes Inducidas / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: Stem Cell Res Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Pluripotentes Inducidas / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: Stem Cell Res Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido