Chinese medicine Bu-Fei decoction attenuates epithelial-mesenchymal transition of non-small cell lung cancer via inhibition of transforming growth factor ß1 signaling pathway in vitro and in vivo.

He, Xi-Ran; Han, Shu-Yan; Li, Xiao-Hong; Zheng, Wen-Xian; Pang, Li-Na; Jiang, Shan-Tong; Li, Ping-Ping

He, Xi-Ran; Han, Shu-Yan; Li, Xiao-Hong; Zheng, Wen-Xian; Pang, Li-Na; Jiang, Shan-Tong; Li, Ping-Ping.

Afiliación

He XR; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address: hexr2011@126.com.
Han SY; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address: shuyanhan@bjmu.edu.cn.
Li XH; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address: hanxiaolemon@163.com.
Zheng WX; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China; Department of Oncology, The Sixth People's Hospital, Shanghai Jiao Ton
Pang LN; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address: 18611066280@163.com.
Jiang ST; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address: wo907152921@126.com.
Li PP; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address: lppma123@sina.com.

J Ethnopharmacol ; 204: 45-57, 2017 May 23.

Article en En | MEDLINE | ID: mdl-28412214

Asunto(s)

Antineoplásicos/farmacología; Medicamentos Herbarios Chinos/farmacología; Transición Epitelial-Mesenquimal/efectos de los fármacos; Factor de Crecimiento Transformador beta1/antagonistas & inhibidores; Células A549; Animales; Antineoplásicos/uso terapéutico; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/patología; Movimiento Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Medicamentos Herbarios Chinos/uso terapéutico; Femenino; Humanos; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patología; Ratones Endogámicos BALB C; Transducción de Señal/efectos de los fármacos; Proteínas Smad/genética; Proteínas Smad/metabolismo; Factor de Crecimiento Transformador beta1/sangre; Factor de Crecimiento Transformador beta1/genética; Factor de Crecimiento Transformador beta1/metabolismo

Palabras clave

3, 5-dicaffeoylquinic acid (PubChem CID: 6474310); 3-caffeoylquinic acid (PubChem CID: 1794427); Asterinin A (PubChem CID: 101667551); Astragaloside I (PubChem CID: 13996685); Astragaloside II (PubChem CID: 71306915); Astragaloside III (PubChem CID: 441905); Astragaloside IV (PubChem CID: 13943297); Astramembranoside B (PubChem CID: 24796110); Bu-Fei decoction; Calycosin (PubChem CID: 5280448); Calycosin-7-O-B-D-glucoside (PubChem CID: 91973796); Citric acid (PubChem CID: 311); Cyclocephalosideâ¡ (PubChem CID: 100927166); Epithelial-mesenchymal transition; Formononetin (PubChem CID: 5280378); Isoastragaloside I (PubChem CID: 60148697); Isoastragaloside II (PubChem CID: 60148655); Lobetyolin (PubChem CID: 53486204); Lobetyolinin (PubChem CID: 5459227); Mulberroside A (PubChem CID: 6443484); Mulberroside C (PubChem CID: 190453); Non-small cell lung cancer; Ononin (PubChem CID: 13287581); Schisandrin (PubChem CID: 23915); Schisantherin A (PubChem CID: 151529); Schisantherin B (PubChem CID: 6438572); Schizandrin B (PubChem CID: 108130); Transforming growth factor ß1; Tumor microenvironment; Verbascoside (PubChem CID: 5281800)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Factor de Crecimiento Transformador beta1 / Transición Epitelial-Mesenquimal / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Ethnopharmacol Año: 2017 Tipo del documento: Article Pais de publicación: Irlanda

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