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Dietary Docosahexaenoic Acid and trans-10, cis-12-Conjugated Linoleic Acid Differentially Alter Oxylipin Profiles in Mouse Periuterine Adipose Tissue.
Adkins, Yuriko; Belda, Benjamin J; Pedersen, Theresa L; Fedor, Dawn M; Mackey, Bruce E; Newman, John W; Kelley, Darshan S.
Afiliación
  • Adkins Y; Western Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, 430 West Health Sciences Drive, Davis, CA, 95616, USA.
  • Belda BJ; Department of Nutrition, University of California, Davis, CA, 95616, USA.
  • Pedersen TL; Western Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, 430 West Health Sciences Drive, Davis, CA, 95616, USA.
  • Fedor DM; Western Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, 430 West Health Sciences Drive, Davis, CA, 95616, USA.
  • Mackey BE; Western Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, 430 West Health Sciences Drive, Davis, CA, 95616, USA.
  • Newman JW; Department of Nutrition, University of California, Davis, CA, 95616, USA.
  • Kelley DS; Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Albany, CA, 94710, USA.
Lipids ; 52(5): 399-413, 2017 05.
Article en En | MEDLINE | ID: mdl-28409336
Diets containing high n-3 polyunsaturated fatty acids (PUFA) decrease inflammation and the incidence of chronic diseases including cardiovascular disease and nonalcoholic fatty liver disease while trans-fatty acids (TFA) intake increases the incidence of these conditions. Some health benefits of n-3 PUFA are mediated through the impact of their oxygenated metabolites, i.e. oxylipins. The TFA, trans-10, cis-12-conjugated linoleic acid (CLA; 18:2n-6) is associated with adipose tissue (AT) inflammation, oxidative stress, and wasting. We examined the impact of a 4-week feeding of 0, 0.5, and 1.5% docosahexaenoic acid (DHA; 22:6n-3) in the presence and absence of 0.5% CLA on AT oxylipin profiles in female C57BL/6N mice. Esterified oxylipins in AT derived from linoleic acid (LNA), alpha-linolenic acid (ALA), arachidonic acid (ARA), eicosapentaenoic acid (EPA), DHA, and putative from CLA were quantified. CLA containing diets reduced AT mass by ~62%. Compared with the control diet, the DHA diet elevated concentrations of EPA-and DHA-derived alcohols and epoxides and LNA-derived alcohols, reduced ARA-derived alcohols, ketones, epoxides, and 6-keto-prostaglandin (PG) F1α (P < 0.05), and had mixed effects on ALA-derived alcohols. Dietary CLA lowered EPA-, DHA-, and ALA-derived epoxides, ARA-derived ketones and epoxides, and ALA-derived alcohols. While dietary CLA induced variable effects in EPA-, DHA-, and LNA-derived alcohols and LNA-derived ketones, it elevated ARA-derived alcohols and PGF1α, PGF2α, and F2-isoprostanes. DHA counteracted CLA-induced effects in 67, 57, 43, and 29% of total DHA-, ARA-, EPA-, and ALA-derived oxylipins, respectively. Thus, CLA elevated proinflammatory oxylipins while DHA increased anti-inflammatory oxylipins and diminished concentration of CLA-induced pro-inflammatory oxylipins in AT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo / Ácidos Docosahexaenoicos / Ácidos Linoleicos Conjugados / Oxilipinas Límite: Animals Idioma: En Revista: Lipids Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo / Ácidos Docosahexaenoicos / Ácidos Linoleicos Conjugados / Oxilipinas Límite: Animals Idioma: En Revista: Lipids Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos