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The Importance of VEGF-KDR Signaling Pathway Genes should Not Be Ignored When the Risk of Developing Multiple Sclerosis is Taken into Consideration.
Mazdeh, Mehrdokht; Noroozi, Rezvan; Gharesouran, Jalal; Sayad, Arezou; Komaki, Alireza; Eftekharian, Mohammad Mahdi; Habibi, Mohsen; Toghi, Mehdi; Taheri, Mohammad.
Afiliación
  • Mazdeh M; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Noroozi R; Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Gharesouran J; Young Researchers and Elite Club, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.
  • Sayad A; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 8th Floor, SBUMS Bldg., Next to Ayatollah Taleghani Hospital, Evin, Tehran, 198396-3113, Iran.
  • Komaki A; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Eftekharian MM; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 8th Floor, SBUMS Bldg., Next to Ayatollah Taleghani Hospital, Evin, Tehran, 198396-3113, Iran.
  • Habibi M; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Toghi M; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Taheri M; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 8th Floor, SBUMS Bldg., Next to Ayatollah Taleghani Hospital, Evin, Tehran, 198396-3113, Iran.
J Mol Neurosci ; 62(1): 73-78, 2017 May.
Article en En | MEDLINE | ID: mdl-28401369
Vascular endothelial growth factor (VEGF) and its receptor kinase insert domain-containing receptor (KDR) pathway trigger the process of angiogenesis as well as inflammation, which contributes to the development and progression of demyelinating lesions in multiple sclerosis. This work is a case-control study comprising of a total of 400 subjects with multiple sclerosis and 400 healthy controls. Participants were subjected to neurological examination and peripheral blood sampling for genotyping. Polymorphisms in the VEGF and KDR genes were assessed using the restriction fragment length polymorphism (RFLP-PCR) method. A significantly higher frequency of the T allele and TT genotype of the VEGF 936C > T (rs3025039) polymorphism was found in the multiple sclerosis group than in the healthy control group (P = 0.01 [OR = 1.41] and P = 0.01 [OR = 3.12], respectively). In addition, VEGF 936C  >  T showed an association with patients in a recessive model. However, the KDR -604T > C (rs2071559) polymorphism showed no significant difference in either allelic or genotype frequency between the two groups. Taken together, the results of the present study suggests that the T allele of the rs3025039 in VEGF gene could be considered a risk factor for developing multiple sclerosis in the Iranian population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Longitud del Fragmento de Restricción / Polimorfismo de Nucleótido Simple / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Factor A de Crecimiento Endotelial Vascular / Esclerosis Múltiple Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: J Mol Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Longitud del Fragmento de Restricción / Polimorfismo de Nucleótido Simple / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Factor A de Crecimiento Endotelial Vascular / Esclerosis Múltiple Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: J Mol Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos