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Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.
Wentsch, Heike K; Walter, Niklas M; Bührmann, Mike; Mayer-Wrangowski, Svenja; Rauh, Daniel; Zaman, Guido J R; Willemsen-Seegers, Nicole; Buijsman, Rogier C; Henning, Melanie; Dauch, Daniel; Zender, Lars; Laufer, Stefan.
Afiliación
  • Wentsch HK; Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
  • Walter NM; Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
  • Bührmann M; Faculty of Chemistry and Chemical Biology, Technische Universität Dortmund, Germany.
  • Mayer-Wrangowski S; Faculty of Chemistry and Chemical Biology, Technische Universität Dortmund, Germany.
  • Rauh D; Faculty of Chemistry and Chemical Biology, Technische Universität Dortmund, Germany.
  • Zaman GJR; Netherlands Translational Research Center B.V. (NTRC), Oss, The Netherlands.
  • Willemsen-Seegers N; Netherlands Translational Research Center B.V. (NTRC), Oss, The Netherlands.
  • Buijsman RC; Netherlands Translational Research Center B.V. (NTRC), Oss, The Netherlands.
  • Henning M; Department of Internal Medicine VIII, University Hospital Tübingen (Germany).
  • Dauch D; Institute of Physiology, Department of Physiology I, Eberhard Karls Universität Tübingen, Germany.
  • Zender L; Department of Internal Medicine VIII, University Hospital Tübingen (Germany).
  • Laufer S; Institute of Physiology, Department of Physiology I, Eberhard Karls Universität Tübingen, Germany.
Angew Chem Int Ed Engl ; 56(19): 5363-5367, 2017 05 02.
Article en En | MEDLINE | ID: mdl-28397331

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Quinasa 14 Activada por Mitógenos / Inhibidores de Proteínas Quinasas / Dibenzocicloheptenos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Quinasa 14 Activada por Mitógenos / Inhibidores de Proteínas Quinasas / Dibenzocicloheptenos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania