Circadian rhythm of adrenergic regulation of adrenocorticotropin and cortisol secretion in man.

Naylor, M R; Krishnan, K R; Manepalli, A N; Ritchie, J C; Wilson, W H; Carroll, B J

Naylor, M R; Krishnan, K R; Manepalli, A N; Ritchie, J C; Wilson, W H; Carroll, B J.

Afiliación

Naylor MR; Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.

J Clin Endocrinol Metab ; 67(2): 404-6, 1988 Aug.

Article en En | MEDLINE | ID: mdl-2839538

RESUMEN

The effects of the alpha-adrenergic agonist methoxamine on the human hypothalamic-pituitary-adrenal axis was assessed by a placebo-controlled study in the morning and one in the evening. A 5-mg iv bolus dose of methoxamine in normal subjects caused a significant rise in plasma ACTH and cortisol concentrations in the morning study. However, no significant change in plasma cortisol or ACTH concentrations was noted during the evening study. These studies suggest the existence of a diurnal variation in alpha 1-adrenergic regulation of the hypothalamic-pituitary-adrenal axis.

Asunto(s)

Hormona Adrenocorticotrópica/metabolismo; Ritmo Circadiano; Hidrocortisona/metabolismo; Receptores Adrenérgicos alfa/fisiología; Adulto; Humanos; Masculino; Metoxamina/farmacología; Factores de Tiempo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocortisona / Receptores Adrenérgicos alfa / Ritmo Circadiano / Hormona Adrenocorticotrópica Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male Idioma: En Revista: J Clin Endocrinol Metab Año: 1988 Tipo del documento: Article Pais de publicación: Estados Unidos

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