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Proteomic analysis of human plasma and peripheral blood mononuclear cells in Systemic Lupus Erythematosus patients.
Pinna, Sara; Pasella, Sara; Deiana, Marta; Baralla, Angela; Mannu, Andrea; Masala, Antonio Giovanni Emilio; Pileri, Piera Veronica; Deiana, Nicola; Scognamillo, Fabrizio; Pala, Carlo; Zinellu, Angelo; Carru, Ciriaco; Deiana, Luca.
Afiliación
  • Pinna S; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
  • Pasella S; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
  • Deiana M; Associazione "L'Isola dei Centenari", Sassari, Italy.
  • Baralla A; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
  • Mannu A; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
  • Masala AGE; Internal Medicine 1, A.O.U. University of Sassari, Sassari, Italy.
  • Pileri PV; Internal Medicine 1, A.O.U. University of Sassari, Sassari, Italy.
  • Deiana N; Associazione "L'Isola dei Centenari", Sassari, Italy.
  • Scognamillo F; Surgical Pathology, A.O.U. University of Sassari, Sassari, Italy.
  • Pala C; Surgical Pathology, A.O.U. University of Sassari, Sassari, Italy.
  • Zinellu A; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
  • Carru C; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
  • Deiana L; Department of Biomedical Sciences, University of Sassari, Sassari, Italy; Associazione "L'Isola dei Centenari", Sassari, Italy. Electronic address: deiana@uniss.it.
J Immunol Methods ; 446: 37-46, 2017 07.
Article en En | MEDLINE | ID: mdl-28390925
Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease with a broad spectrum of clinical presentations and incompletely understood pathogenesis. This autoimmune disease is characterized by alterations in both the innate and adaptive immune system that lead to the loss of immunologic tolerance. In autoimmune diseases particularly in SLE, early diagnosis, flare or remission phases can be difficult to identify. Proteomics can help to find new therapeutic targets and it also could help to better understand the cellular mechanisms. The aim of this study was to observe the variations in plasma and Peripheral Blood Mononuclear Cells (PBMCs) proteome in order to increase our knowledge about pathogenesis and to find possible diagnostic markers and/or therapeutic targets for improving diagnosis and treatment. The comparative proteomic analyses showed that several proteins were differentially expressed in the PBMCs from SLE patients. Among these, PRDX2 may be used as candidate biomarker or target protein for further investigations. In plasma, we showed that plasma clusterin levels increased in SLE patients compared to healthy controls, but this increase is not statistically significant. These proteomic results provide suggestions for understanding the molecular mechanisms of SLE, as well as the physiological changes correlated with SLE disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Proteómica / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Immunol Methods Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Proteómica / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Immunol Methods Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos