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Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner.
Gardener, Samantha L; Rainey-Smith, Stephanie R; Sohrabi, Hamid R; Weinborn, Michael; Verdile, Giuseppe; Fernando, W M A D Binosha; Lim, Yen Ying; Harrington, Karra; Burnham, Samantha; Taddei, Kevin; Masters, Colin L; Macaulay, Stuart L; Rowe, Christopher C; Ames, David; Maruff, Paul; Martins, Ralph N.
Afiliación
  • Gardener SL; Centre of Excellence for Alzheimer's disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Rainey-Smith SR; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia.
  • Sohrabi HR; Centre of Excellence for Alzheimer's disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Weinborn M; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia.
  • Verdile G; Centre of Excellence for Alzheimer's disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Fernando WMADB; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia.
  • Lim YY; Department of Biomedical Sciences, Macquarie University, NSW, Australia.
  • Harrington K; Centre of Excellence for Alzheimer's disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Burnham S; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia.
  • Taddei K; School of Psychology, University of Western Australia, Crawley, WA, Australia.
  • Masters CL; Centre of Excellence for Alzheimer's disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Macaulay SL; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia.
  • Rowe CC; School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University of Technology, Bentley, WA, Australia.
  • Ames D; Centre of Excellence for Alzheimer's disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Maruff P; Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia.
  • Martins RN; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
J Alzheimers Dis ; 58(1): 193-201, 2017.
Article en En | MEDLINE | ID: mdl-28387666
Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ɛ4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-ß (Aß) load in CN older adults, genotyped for APOEɛ4 allele carrier status. Greater carbohydrate intake was associated with poorer performance in verbal memory in APOEɛ4 allele non-carriers, and poorer performance in attention in APOEɛ4 allele carriers. There were no associations between carbohydrate intake and cerebral Aß load. These results provide support to the idea that decreasing carbohydrate intake may offer neurocognitive benefits, with specific cognitive domains affected in an APOE genotype-dependent manner. These findings warrant further investigation utilizing a longitudinal study design.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención / Aprendizaje Verbal / Carbohidratos / Apolipoproteína E4 / Trastornos de la Memoria Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención / Aprendizaje Verbal / Carbohidratos / Apolipoproteína E4 / Trastornos de la Memoria Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos