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High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus.
Lai, Jun S; Pang, Wei Wei; Cai, Shirong; Lee, Yung Seng; Chan, Jerry K Y; Shek, Lynette P C; Yap, Fabian K P; Tan, Kok Hian; Godfrey, Keith M; van Dam, Rob M; Chong, Yap Seng; Chong, Mary F F.
Afiliación
  • Lai JS; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.
  • Pang WW; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
  • Cai S; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
  • Lee YS; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
  • Chan JKY; Duke-NUS Medical School, Singapore; Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore.
  • Shek LPC; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
  • Yap FKP; Duke-NUS Medical School, Singapore; Department of Paediatric Endocrinology, KK Women's and Children's Hospital, Singapore.
  • Tan KH; Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
  • Godfrey KM; MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  • Chong YS; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
  • Chong MFF; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address: ephmcff@nus.edu.sg.
Clin Nutr ; 37(3): 940-947, 2018 06.
Article en En | MEDLINE | ID: mdl-28381340
BACKGROUND & AIMS: B-vitamins and homocysteine may contribute to the development of gestational diabetes mellitus (GDM), but existing studies are inconsistent. We examined the cross-sectional associations of plasma folate, vitamins B6, B12, and homocysteine concentrations with GDM and glycemia in a sample of multi-ethnic Asian pregnant women. METHODS: Plasma concentrations of folate, vitamins B6, B12, homocysteine and glucose were measured at 26-weeks' gestation in 913 pregnant women. GDM was diagnosed using the 1999 World Health Organization criteria. Associations were examined with linear or logistic regression, adjusted for confounders and stratified by ethnicity. RESULTS: Higher plasma folate was associated with higher 2-h glucose and higher odds of GDM [0.15 (0.02, 0.23) per 1-SD increment in folate, OR 1.29 (1.00, 1.60)], mainly among Indian mothers. Higher plasma vitamin B12 and homocysteine were associated with lower fasting and 2-h glucose, and lower odds of GDM [-0.04 (-0.07, -0.01) per 1-SD increment in B12 and -0.09 (-0.18, -0.003) respectively, OR: 0.81 (0.68, 0.97); -0.05 (-0.08, -0.02) per 1-SD increment in homocysteine and -0.12 (-0.21, -0.02) respectively, OR: 0.76 (0.62, 0.92)]. The highest odds of GDM were observed among women with combined vitamin B12 insufficiency and high folate concentration [OR: 1.97 (1.05, 3.68)]. An association between higher vitamin B6 and higher 2-h glucose shifted towards null adjusting for other B-vitamins. CONCLUSIONS: Higher maternal folate coupled with vitamin B12 insufficiency was associated with higher GDM risk. This finding has potential implications for antenatal supplement recommendations but will require confirmation in future studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Deficiencia de Vitamina B 12 / Diabetes Gestacional / Ácido Fólico Tipo de estudio: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Clin Nutr Año: 2018 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Deficiencia de Vitamina B 12 / Diabetes Gestacional / Ácido Fólico Tipo de estudio: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Clin Nutr Año: 2018 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido