"Ghost peaks" of ezetimibe: Solution degradation products of ezetimibe in acetonitrile induced by alkaline impurities from glass HPLC vials.

Jin, Jianyang; Wang, Zhiying; Lin, Jinsheng; Zhu, Wenquan; Gu, Chengzhen; Li, Min

Jin, Jianyang; Wang, Zhiying; Lin, Jinsheng; Zhu, Wenquan; Gu, Chengzhen; Li, Min.

Afiliación

Jin J; Center of Excellence for Modern Analytical Technologies (CEMAT), Huahai Pharmaceutical Co., Ltd, Xunqiao, Linhai, Zhejiang 317024, PR China.
Wang Z; Waters Corp., Shanghai, PR China.
Lin J; Center of Excellence for Modern Analytical Technologies (CEMAT), Huahai Pharmaceutical Co., Ltd, Xunqiao, Linhai, Zhejiang 317024, PR China.
Zhu W; Center of Excellence for Modern Analytical Technologies (CEMAT), Huahai Pharmaceutical Co., Ltd, Xunqiao, Linhai, Zhejiang 317024, PR China.
Gu C; Center of Excellence for Modern Analytical Technologies (CEMAT), Huahai Pharmaceutical Co., Ltd, Xunqiao, Linhai, Zhejiang 317024, PR China.
Li M; Center of Excellence for Modern Analytical Technologies (CEMAT), Huahai Pharmaceutical Co., Ltd, Xunqiao, Linhai, Zhejiang 317024, PR China; Huahai US, Inc., 2001 Eastpark Blvd, Cranbury, NJ 08512, USA. Electronic address: minli88@yahoo.com.

J Pharm Biomed Anal ; 140: 281-286, 2017 Jun 05.

Article en En | MEDLINE | ID: mdl-28376385

Asunto(s)

Cromatografía Líquida de Alta Presión; Acetonitrilos; Estabilidad de Medicamentos; Ezetimiba

Palabras clave

Base-catalyzed; Degradation; Ezetimibe; HPLC vial; LCMS

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatografía Líquida de Alta Presión Idioma: En Revista: J Pharm Biomed Anal Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido

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