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Management and Novel Adjuncts of Necrotizing Soft Tissue Infections.
Cocanour, Christine S; Chang, Phillip; Huston, Jared M; Adams, Charles A; Diaz, Jose J; Wessel, Charles B; Falcione, Bonnie A; Bauza, Graciela M; Forsythe, Raquel A; Rosengart, Matthew R.
Afiliación
  • Cocanour CS; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Chang P; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Huston JM; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Adams CA; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Diaz JJ; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Wessel CB; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Falcione BA; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Bauza GM; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Forsythe RA; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
  • Rosengart MR; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
Surg Infect (Larchmt) ; 18(3): 250-272, 2017 Apr.
Article en En | MEDLINE | ID: mdl-28375805
Necrotizing soft tissue infections (NSTI) have been recognized for millennia and continue to impose considerable burden on both patient and society in terms of morbidity, death, and the allocation of resources. With improvements in the delivery of critical care, outcomes have improved, although disease-specific therapies are lacking. The basic principles of early diagnosis, of prompt and broad antimicrobial therapy, and of aggressive debridement have remained unchanged. Clearly novel and new therapeutics are needed to combat this persistently lethal disease. This review emphasizes the pillars of NSTI management and then summarizes the contemporary evidence supporting the incorporation of novel adjuncts to the pharmacologic and operative foundations of managing this disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fascitis Necrotizante / Desbridamiento / Antiinfecciosos Tipo de estudio: Screening_studies Límite: Humans Idioma: En Revista: Surg Infect (Larchmt) Asunto de la revista: BACTERIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fascitis Necrotizante / Desbridamiento / Antiinfecciosos Tipo de estudio: Screening_studies Límite: Humans Idioma: En Revista: Surg Infect (Larchmt) Asunto de la revista: BACTERIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos