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Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells.
Kräutler, Nike J; Suan, Dan; Butt, Danyal; Bourne, Katherine; Hermes, Jana R; Chan, Tyani D; Sundling, Christopher; Kaplan, Warren; Schofield, Peter; Jackson, Jennifer; Basten, Antony; Christ, Daniel; Brink, Robert.
Afiliación
  • Kräutler NJ; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Suan D; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Butt D; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Bourne K; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Hermes JR; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Chan TD; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Sundling C; St. Vincent's Clinical School, University of New South Wales, Darlinghurst NSW 2010, Australia.
  • Kaplan W; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Schofield P; Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Jackson J; St. Vincent's Clinical School, University of New South Wales, Darlinghurst NSW 2010, Australia.
  • Basten A; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Christ D; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
  • Brink R; Immunology Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
J Exp Med ; 214(5): 1259-1267, 2017 05 01.
Article en En | MEDLINE | ID: mdl-28363897
Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the selective PC differentiation of only high-affinity GC B cells remains unknown. In this study, we show that differentiation into PCs is induced among a discrete subset of high-affinity B cells residing within the light zone of the GC. Initiation of differentiation required signals delivered upon engagement with intact antigen. Signals delivered by T follicular helper cells were not required to initiate differentiation but were essential to complete the differentiation process and drive migration of maturing PCs through the dark zone and out of the GC. This bipartite or two-signal mechanism has likely evolved to both sustain protective immunity and avoid autoantibody production.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Plasmáticas / Linfocitos B / Antígenos de Diferenciación de Linfocitos B / Diferenciación Celular / Linfocitos T Colaboradores-Inductores / Centro Germinal Límite: Animals Idioma: En Revista: J Exp Med Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Plasmáticas / Linfocitos B / Antígenos de Diferenciación de Linfocitos B / Diferenciación Celular / Linfocitos T Colaboradores-Inductores / Centro Germinal Límite: Animals Idioma: En Revista: J Exp Med Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos