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Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions.
Chen, Nai-Tzu; Souris, Jeffrey S; Cheng, Shih-Hsun; Chu, Chia-Hui; Wang, Yu-Chao; Konda, Vani; Dougherty, Urszula; Bissonnette, Marc; Mou, Chung-Yuan; Chen, Chin-Tu; Lo, Leu-Wei.
Afiliación
  • Chen NT; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes Zhunan, Miaoli, Taiwan; Department of Chemistry, National Taiwan University Taipei, Taiwan; Department of Radiology, The University of Chicago, Chicago, IL, USA; Institute of New Drug Development, College of Bi
  • Souris JS; Department of Radiology, The University of Chicago, Chicago, IL, USA.
  • Cheng SH; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes Zhunan, Miaoli, Taiwan; Department of Radiology, The University of Chicago, Chicago, IL, USA.
  • Chu CH; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes Zhunan, Miaoli, Taiwan.
  • Wang YC; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes Zhunan, Miaoli, Taiwan.
  • Konda V; Department of Medicine, The University of Chicago, Chicago, IL, USA.
  • Dougherty U; Department of Medicine, The University of Chicago, Chicago, IL, USA.
  • Bissonnette M; Department of Medicine, The University of Chicago, Chicago, IL, USA.
  • Mou CY; Department of Chemistry, National Taiwan University Taipei, Taiwan.
  • Chen CT; Department of Radiology, The University of Chicago, Chicago, IL, USA.
  • Lo LW; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes Zhunan, Miaoli, Taiwan. Electronic address: lwlo@nhri.org.tw.
Nanomedicine ; 13(6): 1941-1952, 2017 Aug.
Article en En | MEDLINE | ID: mdl-28363770
Colorectal cancer (CRC) is one of the leading causes of cancer-deaths worldwide. Methods for the early in situ detection of colorectal adenomatous polyps and their precursors - prior to their malignancy transformation into CRC - are urgently needed. Unfortunately at present, the primary diagnostic method, colonoscopy, can only detect polyps and carcinomas by shape/morphology; with sessile polyps more likely to go unnoticed than polypoid lesions. Here we describe our development of polyp-targeting, fluorescently-labeled mesoporous silica nanoparticles (MSNs) that serve as targeted endoscopic contrast agents for the early detection of colorectal polyps and cancer. In vitro cell studies, ex vivo histopathological analysis, and in vivo colonoscopy and endoscopy of murine colorectal cancer models, demonstrate significant binding specificity of our nanoconstructs to pathological lesions via targeting aberrant α-L-fucose expression. Our findings strongly suggest that lectin-functionalized fluorescent MSNs could serve as a promising endoscopic contrast agent for in situ diagnostic imaging of premalignant colonic lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Neoplasias Colorrectales / Pólipos del Colon / Dióxido de Silicio / Endoscopía / Nanopartículas / Lectinas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans / Male Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Neoplasias Colorrectales / Pólipos del Colon / Dióxido de Silicio / Endoscopía / Nanopartículas / Lectinas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans / Male Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos