Complement-mediated cytolytic activity associated with cytomegalovirus complement-fixing IgM antibody.

Booth, J C; Mohammed, H S

Booth, J C; Mohammed, H S.

Afiliación

Booth JC; Department of Virology, St. George's Hospital Medical School, University of London, England.

J Med Virol ; 24(3): 351-9, 1988 Mar.

Article en En | MEDLINE | ID: mdl-2835430

RESUMEN

Cytomegalovirus-specific complement-fixing IgM (CMV CF-IgM) antibody was detected in 12/84 (14.3 percent) sera containing CMV-specific IgM. Higher titres were obtained by using a purified antigen preparation containing enveloped virus particles and membrane fragments when compared with a crude extract of infected cells, suggesting that the CF component of CMV IgM reacts predominantly with antigens on the surface of the infected cells. This also accounts for its complement-mediated cytolytic activity. Neither CMV-specific non-complement-fixing IgM nor CMV-specific IgG demonstrates cytolytic activity.

Asunto(s)

Anticuerpos Antivirales/inmunología; Citomegalovirus/inmunología; Inmunoglobulina M/inmunología; Citotoxicidad Celular Dependiente de Anticuerpos; Antígenos Virales/inmunología; Proteínas del Sistema Complemento/inmunología; Infecciones por Citomegalovirus/inmunología; Humanos; Técnicas In Vitro

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina M / Citomegalovirus / Anticuerpos Antivirales Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Med Virol Año: 1988 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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