Your browser doesn't support javascript.
loading
Photocontrolled SiRNA Delivery and Biomarker-Triggered Luminogens of Aggregation-Induced Emission by Up-Conversion NaYF4:Yb3+Tm3+@SiO2 Nanoparticles for Inducing and Monitoring Stem-Cell Differentiation.
Li, Jinming; Leung, Chris Wai Tung; Wong, Dexter Siu Hong; Xu, Jianbin; Li, Rui; Zhao, Yueyue; Yung, Chris Yu Yee; Zhao, Engui; Tang, Ben Zhong; Bian, Liming.
Afiliación
  • Li J; Division of Biomedical Engineering , The Chinese University of Hong Kong , Hong Kong , China.
  • Leung CWT; Department of Chemistry, Institute of Molecular Functional Materials , The Hong Kong University of Science and Technology (HKUST) , Kowloon, Hong Kong , China.
  • Wong DSH; Division of Biomedical Engineering , The Chinese University of Hong Kong , Hong Kong , China.
  • Xu J; Division of Biomedical Engineering , The Chinese University of Hong Kong , Hong Kong , China.
  • Li R; Division of Biomedical Engineering , The Chinese University of Hong Kong , Hong Kong , China.
  • Zhao Y; Department of Chemistry, Institute of Molecular Functional Materials , The Hong Kong University of Science and Technology (HKUST) , Kowloon, Hong Kong , China.
  • Yung CYY; Department of Chemistry, Institute of Molecular Functional Materials , The Hong Kong University of Science and Technology (HKUST) , Kowloon, Hong Kong , China.
  • Zhao E; Department of Chemistry, Institute of Molecular Functional Materials , The Hong Kong University of Science and Technology (HKUST) , Kowloon, Hong Kong , China.
  • Tang BZ; Department of Chemistry, Institute of Molecular Functional Materials , The Hong Kong University of Science and Technology (HKUST) , Kowloon, Hong Kong , China.
  • Bian L; Division of Biomedical Engineering , The Chinese University of Hong Kong , Hong Kong , China.
ACS Appl Mater Interfaces ; 11(25): 22074-22084, 2019 Jun 26.
Article en En | MEDLINE | ID: mdl-28350958
Controlling the differentiation of stem cells and monitoring cell differentiation has attracted much research interest since the discovery of stem cells. In this regard, a novel near-infrared (NIR) light-activated nanoplatform is obtained by encapsulating the photoactivatable caged compound (DMNPE/siRNA) and combining a MMP13 cleaved imaging peptide-tetrapheny-lethene (TPE) unit conjugated with the mesoporous silica-coated up-conversion nanoparticles (UCNPs) for the remote control of cell differentiation and, simultaneously, for the real-time monitoring of differentiation. Upon NIR light illumination, the photoactivated caged compound is activated, and the siRNA is released from UCNPs, allowing controlled differentiation of stem cells by light. More importantly, MMP13 enzyme triggered by osteogenic differentiation would effectively cleave the TPE probe peptide, thereby allowing the real-time monitoring of differentiation in living stem cells by aggregation-induced emission (AIE).
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Itrio / Dióxido de Silicio / ARN Interferente Pequeño / Nanopartículas Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Itrio / Dióxido de Silicio / ARN Interferente Pequeño / Nanopartículas Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos