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Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome.
Marcondes, Rodrigo R; Maliqueo, Manuel; Fornes, Romina; Benrick, Anna; Hu, Min; Ivarsson, Niklas; Carlström, Mattias; Cushman, Samuel W; Stenkula, Karin G; Maciel, Gustavo A R; Stener-Victorin, Elisabet.
Afiliación
  • Marcondes RR; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Disciplina de Ginecologia, Laboratório de Ginecologia Estrutural e Molecular (LIM 58), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Maliqueo M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Endocrinology and Metabolism Laboratory, Department of Medicine, West Division, University of Chile, Santiago, Chile.
  • Fornes R; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Benrick A; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; School of Health and Education, University of Skövde, Skövde, Sweden.
  • Hu M; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Ivarsson N; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Carlström M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Cushman SW; Experimental Diabetes, Metabolism, and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA.
  • Stenkula KG; Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
  • Maciel GAR; Disciplina de Ginecologia, Laboratório de Ginecologia Estrutural e Molecular (LIM 58), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Stener-Victorin E; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address: elisabet.stener-victorin@ki.se.
Mol Cell Endocrinol ; 448: 66-76, 2017 06 15.
Article en En | MEDLINE | ID: mdl-28344042
Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat. DHT-exposed mice had increased body weight, increased number of large mesenteric adipocytes. LET-exposed mice displayed increased body weight and fat mass, decreased insulin sensitivity, increased frequency of small adipocytes and increased expression of genes related to lipolysis in mesenteric fat. In both models, exercise decreased fat mass and inguinal and mesenteric adipose tissue expression of Notch pathway genes, and restored altered mesenteric adipocytes morphology. In conclusion, exercise restored mesenteric adipocytes morphology in DHT- and LET-exposed mice, and insulin sensitivity and mesenteric expression of lipolysis-related genes in LET-exposed mice. Benefits could be explained by downregulation of Notch, and modulation of browning and lipolysis pathways in the adipose tissue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Tejido Adiposo Blanco Límite: Animals Idioma: En Revista: Mol Cell Endocrinol Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Irlanda
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Tejido Adiposo Blanco Límite: Animals Idioma: En Revista: Mol Cell Endocrinol Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Irlanda