Your browser doesn't support javascript.
loading
Cold Lake Blend diluted bitumen toxicity to the early development of Japanese medaka.
Madison, Barry N; Hodson, Peter V; Langlois, Valerie S.
Afiliación
  • Madison BN; Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Canada; School of Environmental Studies, Queen's University, Kingston, ON, Canada.
  • Hodson PV; School of Environmental Studies, Queen's University, Kingston, ON, Canada.
  • Langlois VS; Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Canada; School of Environmental Studies, Queen's University, Kingston, ON, Canada. Electronic address: Valerie.Langlois@rmc.ca.
Environ Pollut ; 225: 579-586, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28336089
Diluted bitumen (dilbit) from Alberta oil sands (Canada) is transported across major continental watersheds, yet little is known about its toxicity to fish if spilled into aquatic environments. The toxicity of Cold Lake (CLB) dilbit was assessed for medaka embryos (Oryzias latipes) exposed to water accommodated fractions (WAF) and chemically-enhanced WAF (CEWAF) using Corexit®EC9500A as dispersant. The effects of CLB toxicity were similar to conventional crude oils and Access Western Blend (AWB) dilbit. The prevalence of malformations and cyp1a mRNA synthesis in hatched fish increased monotonically with concentration during WAF and CEWAF treatments and provided a novel indicator of dilbit PAH toxicity. Apart from nfe2 (an antioxidant transcription factor), there were no statistically significant monotonic exposure-responses of ahr, arnt2, cat, sod, gpx, gst, gsr, g6pdh, p53, and hsp70 transcripts at total polycyclic aromatic hydrocarbons (TPAH) concentrations bracketing EC50s for embryotoxicity (WAF ≅ 3 µg/L; CEWAF ≅ 0.1 µg/L TPAH). Based on measured TPAH concentrations in exposure test solutions, CLB dilbit was 6-10 fold more toxic to medaka than AWB during chronic exposures. Lack of direct monotonic gene transcription responses to increasing oil concentrations during exposures that were embryotoxic suggests that the capacity of the oxidative stress response is limited in earlier lifestages or that differences exist among species in mechanisms of toxicity. This study provides a comparative framework for identifying suitable biomarkers and toxicity methods for those fish species in sensitive lifestages at highest risk of Canadian oil sands dilbit exposure following a spill in the freshwater environment.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Oryzias / Embrión no Mamífero / Yacimiento de Petróleo y Gas / Hidrocarburos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Oryzias / Embrión no Mamífero / Yacimiento de Petróleo y Gas / Hidrocarburos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido