The Effect of Nitroglycerin on Arterial Stiffness of the Aorta and the Femoral-Tibial Arteries.
J Atheroscler Thromb
; 24(10): 1048-1057, 2017 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-28331159
AIM: The effect of nitroglycerin on proper arterial stiffness of the arterial tree has not been fully clarified. The cardio-ankle vascular index (CAVI), which is an application of the stiffness parameter ß theory on the arterial tree from the origin of the aorta to the ankle, was developed recently. Furthermore, the stiffness of the aorta (heart-thigh ß (htBeta)) and of the femoral-tibial arteries (thigh to ankle ß (taBeta)) could be monitored by applying the same theory. The effects of nitroglycerin on CAVI, htBeta, and taBeta were studied comparing the values of healthy people and those of arteriosclerotic patients. METHODS: The subjects were healthy people (CAVI ï¼7.5, n=25) and arteriosclerotic patients (CAVI ï¼9, n=25). Nitroglycerin (0.3 mg) was administrated sublingually, and various arterial stiffness indices were measured at one-minute intervals for a period of 20 minutes using Vasera VS-1500 (Fukuda Denshi, Tokyo). RESULTS: After the administration of nitroglycerin in healthy people, CAVI decreased significantly after 5 min. [from 6.76(6.32-7.27) to 5.50(4.70-6.21), Pï¼0.05], and recovered after 15 min. htBeta [from 5.10(4.76-5.76) to 3.96(3.35-4.79), Pï¼0.05], and taBeta [from 14.41(10.80-16.33) to 10.72 (9.19-13.01), Pï¼0.05] also decreased significantly. In arteriosclerotic patients, CAVI decreased after 5 min. [from 10.47(9.67-11.29) to 9.71(8.74-10.57), Pï¼0.05] and recovered after 15 min. htBeta did not significantly change [from 12.00(11.46-13.21) to 11.81(10.14-13.83), ns], but taBeta decreased significantly [from 18.55(12.93-23.42) to 12.37(9.68-16.99), Pï¼0.05]. CONCLUSION: These results indicate that a nitroglycerin-induced decrease of arterial stiffness is more prominent in muscular arteries than in elastic arteries, and this effect was preserved much more prominently in arteriosclerotic patients than in healthy people.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aorta
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Arterias Tibiales
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Nitroglicerina
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Arteria Femoral
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Rigidez Vascular
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Atheroscler Thromb
Asunto de la revista:
ANGIOLOGIA
Año:
2017
Tipo del documento:
Article
Pais de publicación:
Japón