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Modelling mixing within the dead space of the lung improves predictions of functional residual capacity.
Harrison, Chris D; Phan, Phi Anh; Zhang, Cathy; Geer, Daniel; Farmery, Andrew D; Payne, Stephen J.
Afiliación
  • Harrison CD; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK. Electronic address: christopher.harrison@strath.ac.uk.
  • Phan PA; Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
  • Zhang C; New College, University of Oxford, Holywell Street, Oxford, OX1 3BN, UK.
  • Geer D; The Queen's College, University of Oxford, High Street, Oxford, OX1 4AW, UK.
  • Farmery AD; Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
  • Payne SJ; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK. Electronic address: stephen.payne@eng.ox.ac.uk.
Respir Physiol Neurobiol ; 242: 12-18, 2017 08.
Article en En | MEDLINE | ID: mdl-28323205
Routine estimation of functional residual capacity (FRC) in ventilated patients has been a long held goal, with many methods previously proposed, but none have been used in routine clinical practice. This paper proposes three models for determining FRC using the nitrous oxide concentration from the entire expired breath in order to improve the precision of the estimate. Of the three models proposed, a dead space with two mixing compartments provided the best results, reducing the mean limits of agreement with the FRC measured by whole body plethysmography by up to 41%. This moves away from traditional lung models, which do not account for mixing within the dead space. Compared to literature values for FRC, the results are similar to those obtained using helium dilution and better than the LUFU device (Dräger Medical, Lubeck, Germany), with significantly better limits of agreement compared to plethysmography.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espacio Muerto Respiratorio / Capacidad Residual Funcional / Pulmón / Modelos Biológicos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Respir Physiol Neurobiol Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espacio Muerto Respiratorio / Capacidad Residual Funcional / Pulmón / Modelos Biológicos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Respir Physiol Neurobiol Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos