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Evaluation of the pharmacokinetics of imipenem following regional limb perfusion using the saphenous and the cephalic veins in standing horses.
Kelmer, G; Tatz, A J; Kdoshim, E; Britzi, M; Segev, G.
Afiliación
  • Kelmer G; Large Animal Department, Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture Food and Environment, Hebrew University of Jerusalem, Rehovot, Israel. Electronic address: gal.kelmer@mail.huji.ac.il.
  • Tatz AJ; Large Animal Department, Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture Food and Environment, Hebrew University of Jerusalem, Rehovot, Israel.
  • Kdoshim E; Large Animal Department, Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture Food and Environment, Hebrew University of Jerusalem, Rehovot, Israel.
  • Britzi M; The National Residue Control Laboratory, Kimron Veterinary Institute, Bet Dagan, Israel.
  • Segev G; Small Animal Department, Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture Food and Environment, Hebrew University of Jerusalem, Rehovot, Israel.
Res Vet Sci ; 114: 64-68, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28319829
This prospective experimental study goal was to determine the pharmacokinetics of imipenem after intravenous regional limb perfusion (IV-RLP) in standing horses. Nine horses participated in the study; that was approved by the University Animal Care and Use Committee. One thoracic limb or one pelvic limb of each horse was randomly selected. After the veins were catheterized, an Esmarch bandage tourniquet was applied and the catheter was injected with a solution containing 500mg of imipenem. Synovial fluid samples were collected from the fetlock joint and blood samples were collected from the jugular vein. All samples were analyzed for imipenem concentration using liquid chromatography mass spectrometry. Cmax of imipenem in the fetlock joint using the cephalic and the saphenous vein was 87 and 60µg/mL, respectively. The results indicate that by performing IV-RLP using the cephalic/saphenous, one can achieve imipenem concentrations in the fetlock joint that are well above the MIC of most susceptible pathogens including resistant bacteria such as Methicillin Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Thus, with selective; judicious use, RLP with imipenem can markedly increase treatment efficacy of severe distal limb infections in horses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imipenem / Miembro Anterior / Caballos / Antibacterianos Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Res Vet Sci Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imipenem / Miembro Anterior / Caballos / Antibacterianos Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Res Vet Sci Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido