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Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates.
Doloff, Joshua C; Veiseh, Omid; Vegas, Arturo J; Tam, Hok Hei; Farah, Shady; Ma, Minglin; Li, Jie; Bader, Andrew; Chiu, Alan; Sadraei, Atieh; Aresta-Dasilva, Stephanie; Griffin, Marissa; Jhunjhunwala, Siddharth; Webber, Matthew; Siebert, Sean; Tang, Katherine; Chen, Michael; Langan, Erin; Dholokia, Nimit; Thakrar, Raj; Qi, Meirigeng; Oberholzer, Jose; Greiner, Dale L; Langer, Robert; Anderson, Daniel G.
Afiliación
  • Doloff JC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Veiseh O; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Vegas AJ; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
  • Tam HH; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Farah S; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Ma M; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
  • Li J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Bader A; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Chiu A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Sadraei A; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
  • Aresta-Dasilva S; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Griffin M; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Jhunjhunwala S; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
  • Webber M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Siebert S; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Tang K; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Chen M; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Langan E; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Dholokia N; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Thakrar R; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Qi M; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Oberholzer J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Greiner DL; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
  • Langer R; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
  • Anderson DG; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
Nat Mater ; 16(6): 671-680, 2017 06.
Article en En | MEDLINE | ID: mdl-28319612
Host recognition and immune-mediated foreign body response to biomaterials can compromise the performance of implanted medical devices. To identify key cell and cytokine targets, here we perform in-depth systems analysis of innate and adaptive immune system responses to implanted biomaterials in rodents and non-human primates. While macrophages are indispensable to the fibrotic cascade, surprisingly neutrophils and complement are not. Macrophages, via CXCL13, lead to downstream B cell recruitment, which further potentiated fibrosis, as confirmed by B cell knockout and CXCL13 neutralization. Interestingly, colony stimulating factor-1 receptor (CSF1R) is significantly increased following implantation of multiple biomaterial classes: ceramic, polymer and hydrogel. Its inhibition, like macrophage depletion, leads to complete loss of fibrosis, but spares other macrophage functions such as wound healing, reactive oxygen species production and phagocytosis. Our results indicate that targeting CSF1R may allow for a more selective method of fibrosis inhibition, and improve biomaterial biocompatibility without the need for broad immunosuppression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis e Implantes / Materiales Biocompatibles / Reacción a Cuerpo Extraño / Receptores de Factor Estimulante de Colonias de Granulocitos y Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Mater Asunto de la revista: CIENCIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis e Implantes / Materiales Biocompatibles / Reacción a Cuerpo Extraño / Receptores de Factor Estimulante de Colonias de Granulocitos y Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Mater Asunto de la revista: CIENCIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido