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Increasing HIV-1 subtype diversity in seven states, United States, 2006-2013.
Oster, Alexandra M; Switzer, William M; Hernandez, Angela L; Saduvala, Neeraja; Wertheim, Joel O; Nwangwu-Ike, Ndidi; Ocfemia, M Cheryl; Campbell, Ellsworth; Hall, H Irene.
Afiliación
  • Oster AM; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: AOster@cdc.gov.
  • Switzer WM; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Hernandez AL; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Saduvala N; ICF International, Atlanta, GA.
  • Wertheim JO; ICF International, Atlanta, GA; Department of Medicine, University of California, San Diego.
  • Nwangwu-Ike N; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Ocfemia MC; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Campbell E; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Hall HI; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Ann Epidemiol ; 27(4): 244-251.e1, 2017 04.
Article en En | MEDLINE | ID: mdl-28318764
PURPOSE: The aim of the analysis was to explore HIV-1 subtype diversity in the United States and understand differences in prevalence of non-B subtypes and circulating recombinant forms (CRFs) between demographic/risk groups and over time. METHODS: We included HIV-1 polymerase sequences reported to the National HIV Surveillance System for HIV infections diagnosed during 2006-2013 in seven states. We assigned subtype or CRF using the automated subtyping tool COMET, assessed subtype/CRF prevalence by demographic characteristics and country of birth, and determined changes in subtype/CRF by HIV diagnosis year. RESULTS: Of 32,968 sequences, 30,757 (93.3%) were subtype B. The most common non-B subtypes and CRFs were C (1.6%), CRF02_AG (1.4%), A (0.6%), CRF01_AE (0.5%), and G (0.3%). Elevated percentages of non-B infections occurred among persons aged <13 years at diagnosis (40.9%), Asians (32.1%), persons born outside the United States (22.6%), and persons with infection attributable to heterosexual contact (12.0%-15.0%). Prevalence of non-B infections increased from 5.9% in 2006 to 8.5% in 2013. CONCLUSIONS: Subtype B continues to predominate in the United States. However, the percentage of non-B infections has grown in recent years, and numerous demographic subgroups have much higher prevalence. Subgroups and areas with high prevalence of non-B infections might represent sub-epidemics meriting further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Ann Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Ann Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos