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The medicinal plants in the control of tuberculosis: Laboratory study on medicinal plants from the Northern Area of Pakistan.
Ullah, Sami; Hussain, Shah; Khan, Sadiq Noor; Khurram, Mohammad; Khan, Iqbal; Khan, Murad Ali.
Afiliación
  • Ullah S; Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
  • Hussain S; Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
  • Khan SN; Department of Medical Lab Technology, University of Haripur, Haripur, Pakistan.
  • Khurram M; Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Pakistan.
  • Khan I; Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
  • Khan MA; Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
Int J Mycobacteriol ; 6(1): 102-105, 2017.
Article en En | MEDLINE | ID: mdl-28317814
BACKGROUND: Tuberculosis (TB) ranks as the second leading cause of deaths due to infectious diseases. Although global efforts have been made to control TB, still, this is a serious threat as Mycobacterium tuberculosis (MTB) produced resistance against both the first- and second-line drugs. The increasing incidence of multidrug-resistant, extremely drug resistant, and totally drug-resistant TB worldwide requires extra efforts to search for new anti-TB drugs. MATERIALS AND METHODS: The present study evaluated the antimycobacterial activities of Citrullus colocynthis, Calotropis procera, Ricinus communis, Capparis decidua, and Fagonia cretica plants' extracts against rifampicin-sensitive (H37Rv) and rifampicin-resistant (TMC331) strains of MTB. RESULTS: Out of 44 extracts, 19 extracts were found active against H37Rv sensitive strain. Highest activities were observed in chloroform extract of C. colocynthis (leaves) and n-hexane extract of R. communis (seeds) with minimum inhibitory concentration values of 2.5 mg/ml each. CONCLUSIONS: Results show antimycobacterial potential in some of the fractions of studied plants that may be utilized further for isolation of active compounds and as a possible cure against TB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Extractos Vegetales / Descubrimiento de Drogas / Mycobacterium tuberculosis / Antituberculosos Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Int J Mycobacteriol Año: 2017 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Extractos Vegetales / Descubrimiento de Drogas / Mycobacterium tuberculosis / Antituberculosos Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Int J Mycobacteriol Año: 2017 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: India