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Cardiac fibrosis in the ageing heart: Contributors and mechanisms.
Lu, Lu; Guo, Jingbin; Hua, Yue; Huang, Kevin; Magaye, Ruth; Cornell, Jake; Kelly, Darren J; Reid, Christopher; Liew, Danny; Zhou, Yingchun; Chen, Aihua; Xiao, Wei; Fu, Qiang; Wang, Bing Hui.
Afiliación
  • Lu L; Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
  • Guo J; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
  • Hua Y; Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
  • Huang K; Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Magaye R; Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
  • Cornell J; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
  • Kelly DJ; Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
  • Reid C; Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
  • Liew D; Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
  • Zhou Y; Department of Medicine, St Vincent's Hospital, University of Melbourne, Melbourne, Vic., Australia.
  • Chen A; Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
  • Xiao W; NHMRC Cardiovascular Centre of Research Excellence, School of Public Health, Curtin University, Perth, WA, Australia.
  • Fu Q; Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
  • Wang BH; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Clin Exp Pharmacol Physiol ; 44 Suppl 1: 55-63, 2017 12.
Article en En | MEDLINE | ID: mdl-28316086
Cardiac fibrosis refers to an excessive deposition of extracellular matrix (ECM) in cardiac tissue. Fibrotic tissue is stiffer and less compliant, resulting in subsequent cardiac dysfunction and heart failure. Cardiac fibrosis in the ageing heart may involve activation of fibrogenic signalling and inhibition of anti-fibrotic signalling, leading to an imbalance of ECM turnover. Excessive accumulation of ECM such as collagen in older patients contributes to progressive ventricular dysfunction. Overexpression of collagen is derived from various sources, including higher levels of fibrogenic growth factors, proliferation of fibroblasts and cellular transdifferentiation. These may be triggered by factors, such as oxidative stress, inflammation, hypertension, cellular senescence and cell death, contributing to age-related fibrotic cardiac remodelling. In this review, we will discuss the fibrogenic contributors in age-related cardiac fibrosis, and the potential mechanisms by which fibrogenic processes can be interrupted for therapeutic intent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Senescencia Celular / Remodelación Ventricular / Miocitos Cardíacos / Matriz Extracelular / Insuficiencia Cardíaca / Cardiomiopatías Límite: Animals / Humans Idioma: En Revista: Clin Exp Pharmacol Physiol Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Senescencia Celular / Remodelación Ventricular / Miocitos Cardíacos / Matriz Extracelular / Insuficiencia Cardíaca / Cardiomiopatías Límite: Animals / Humans Idioma: En Revista: Clin Exp Pharmacol Physiol Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Australia