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Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes.
Østergaard, J A; Thiel, S; Hoffmann-Petersen, I T; Hovind, P; Parving, H-H; Tarnow, L; Rossing, P; Hansen, T K.
Afiliación
  • Østergaard JA; Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
  • Thiel S; The Danish Diabetes Academy, Odense, Denmark.
  • Hoffmann-Petersen IT; Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
  • Hovind P; Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
  • Parving HH; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Tarnow L; Department of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Rossing P; Steno Diabetes Center, Gentofte, Denmark.
  • Hansen TK; Nordsjaellands Hospital, Hillerød, Denmark.
Diabetes Metab Res Rev ; 33(5)2017 07.
Article en En | MEDLINE | ID: mdl-28303635
BACKGROUND: Evidence links the lectin pathway of complement activation to diabetic kidney disease. Upon carbohydrate-recognition by pattern-recognition molecules, eg, mannan-binding lectin (MBL), the MBL-associated serine protease (MASP-2) is activated and initiates the complement cascade. The MASP2 gene encodes MASP-2 and the alternative splice product MBL-associated protein 19 (MAp19). Both MAp19 and MASP-2 circulate in complex with MBL. We tested the hypothesis that MAp19 and MASP-2 concentrations predict the risk of incident microalbuminuria. METHODS: Baseline MAp19 and MASP-2 were measured in 270 persons with newly diagnosed type 1 diabetes tracked for incidence of persistent microalbuminuria in a prospective observational 18-year-follow-up study. RESULTS: Seventy-five participants (28%) developed microalbuminuria during follow-up. MBL-associated protein 19 concentrations were higher in participants that later progressed to microalbuminuria as compared with those with persistent normoalbuminuria (268 ng/mL [95% CI, 243-293] vs 236 ng/mL [95% CI, 223-250], P = .02). Participants with MAp19 concentration within the highest quartile of the cohort had an increased risk of microalbuminuria as compared with participants with MAp19 concentration within the combined lower 3 quartiles in unadjusted Cox analysis, hazard ratio 1.86 ([95% CI, 1.17-2.96], P = .009). This remained significant in adjusted models, eg, adjusting for age, sex, HbA1c , systolic blood pressure, urinary albumin excretion, smoking, serum creatinine, and serum cholesterol. MBL-associated serine protease concentration was not associated with incidence of microalbuminuria. CONCLUSIONS: In conclusion, the results show an association between baseline MAp19 concentration and the incidence of microalbuminuria in an 18-year-follow-up study on persons with newly diagnosed type 1 diabetes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 / Albuminuria / Serina Proteasas Asociadas a la Proteína de Unión a la Manosa Tipo de estudio: Diagnostic_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Diabetes Metab Res Rev Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 / Albuminuria / Serina Proteasas Asociadas a la Proteína de Unión a la Manosa Tipo de estudio: Diagnostic_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Diabetes Metab Res Rev Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido