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Effects of palmitoyl-KVK-L-ascorbic acid on skin wrinkles and pigmentation.
Kim, Hyeong Mi; An, Hyo Sun; Bae, Jung-Soo; Kim, Jung Yun; Choi, Chi Ho; Kim, Ju Yeon; Lim, Joo Hyuck; Choi, Joon-Hun; Song, Hyunnam; Moon, Sung Ho; Park, Young Jun; Chang, Shin-Jae; Choi, Sun Young.
Afiliación
  • Kim HM; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • An HS; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • Bae JS; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • Kim JY; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • Choi CH; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • Kim JY; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • Lim JH; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • Choi JH; Celltrion Chemical Research Institute, Yongin, Republic of Korea.
  • Song H; Celltrion Chemical Research Institute, Yongin, Republic of Korea.
  • Moon SH; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • Park YJ; Celltrion Chemical Research Institute, Yongin, Republic of Korea.
  • Chang SJ; Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
  • Choi SY; Department of Dermatology, Seoul Paik Hospital, Inje University College of Medicine, Mareunnae-ro 9, Jung-gu, Seoul, Republic of Korea. sun02ya@naver.com.
Arch Dermatol Res ; 309(5): 397-402, 2017 Jul.
Article en En | MEDLINE | ID: mdl-28303328
Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl-KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial. Our results confirmed that the expression of type Ι collagen in dermal fibroblast cells treated with palmitoyl-KVK-L-ascorbic acid (0.1-4 µg/mL) increased in a dose-dependent manner. In B16F1 cells, treatment with 20 µg/mL palmitoyl-KVK-L-ascorbic acid reduced the melanin content by approximately 20% compared to alpha-melanocyte stimulating hormone treatment. In the clinical trial, application of palmitoyl-KVK-L-ascorbic acid cream led to an improvement in skin roughness and lightness in 12 and 8 weeks, respectively. Our data show that palmitoyl-KVK-L-ascorbic acid is an effective anti-aging agent that reduces wrinkles and abnormal skin pigmentation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Ácido Ascórbico / Envejecimiento de la Piel / Colágeno / Preparaciones para Aclaramiento de la Piel Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Arch Dermatol Res Año: 2017 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Ácido Ascórbico / Envejecimiento de la Piel / Colágeno / Preparaciones para Aclaramiento de la Piel Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Arch Dermatol Res Año: 2017 Tipo del documento: Article Pais de publicación: Alemania